Using Biomarkers to Predict Extubation Failure in ICU Patients
The Value of Repeated Biomarker Measurements During an SBT to Predict Extubation Failure in Mechanically Ventilated ICU Patients
This study is testing if measuring certain biomarkers during breathing trials can help predict if ICU patients on ventilators will successfully breathe on their own after being taken off the machine.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 266 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Erasmus Medical Center Academic / other |
| Locations | 1 site (Rotterdam, Zuid-Holland) |
| Trial ID | NCT05637099 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the predictive value of repeated biomarker measurements during spontaneous breathing trials (SBTs) for determining the risk of extubation failure in mechanically ventilated ICU patients. The study will involve adult patients who have been on mechanical ventilation for over 48 hours and meet specific readiness-to-wean criteria. By analyzing various biomarkers, such as NT-proBNP and hsTroponin-T, the researchers hope to improve the accuracy of extubation readiness assessments. The study will be conducted across multiple centers, collecting clinically available data alongside biomarker measurements and other assessments.
Who should consider this trial
Good fit: Ideal candidates are adult ICU patients who have been mechanically ventilated for more than 48 hours and meet the criteria for readiness to wean.
Not a fit: Patients with upper airway obstruction requiring steroid treatment or those with terminal illness may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the ability to predict extubation failure, potentially reducing the need for reintubation and improving patient outcomes in the ICU.
How similar studies have performed: While the use of biomarkers in this context is not extensively studied, the approach has shown promise in related areas of critical care.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged ≥18 years * Mechanically ventilated for more than 48 hours * Fulfilling readiness-to wean criteria * Written informed consent from the patient or his/her legal representative Exclusion Criteria: * Patients with risk factors for laryngeal oedema and a negative cuff leak test (indicating upper airway obstruction with need for steroid treatment) * Planned replacement of the endotracheal tube for a tracheostomy * Terminal illness
Where this trial is running
Rotterdam, Zuid-Holland
- Erasmus MC — Rotterdam, Zuid-Holland, Netherlands (Recruiting)
Study contacts
- Principal investigator: H. Endeman, Dr. — Erasmus Medical Center
- Study coordinator: C. Groenland, Drs.
- Email: c.groenland@erasmusmc.nl
- Phone: +31 6 29691879
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.