Using beetroot juice to prevent kidney damage during heart procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of beetroot juice supplementation in preventing contrast-induced nephropathy in patients hospitalized for non-ST elevation acute coronary syndrome who are at high risk for kidney injury. Participants will be divided into two groups: one receiving beetroot juice along with standard care, and the other receiving standard care alone. The intervention involves consuming 500 mL of beetroot juice daily for seven days or until discharge, while both groups will receive additional therapies to prevent kidney damage if needed. The study seeks to determine if the inorganic nitrates in beetroot juice can protect kidney function during cardiac catheterizations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of Acute Coronary Syndrome without persistent ST segment elevation, with recommendation for invasive management according to the actual Clinical practice guidelines
* At least moderate or high risk of nephropathy associated with iodinated contrast (Mehran score (without including contrast volume) ≥ 6).

Exclusion Criteria:

* \<18 years old or without capacity to give consent.
* Refusal to participate in the study.
* Known hypersensitivity to beetroot or any of its allergens.
* Pregnant.
* Inability to take food orally
* Serious illnesses (not related to ACS or kidney failure), which limits their life expectancy to a period predictably less than 1 year.
* On dialysis or predialysis at the time of inclusion.
* ACS with persistent ST segment elevation before inclusion.
* Shock or inotrope dependence at the time of inclusion
* PCI already performed before inclusion.
* Patients receiving intravenous nitroglycerin for \> 1 hour before inclusion

Where it's running

• Hospital Universitario Santa Lucía
  Cartagena, Spain Recruiting

Study contacts

• Study coordinator: Jose Manuel Andreu Cayuelas, PhD
• Email: jmandreu@msn.com
• Phone: +34 968 12 86 00

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.