Oral versus IV hydration to prevent contrast-related kidney injury after CT in the ER
Official title: Evaluation of the Effectiveness of Oral Hydration Compared to Intravenous Hydration in Preventing Contrast-Associated Acute Kidney Injury in the Emergency Department : A Randomized Controlled Non-Inferiority Trial
Run by Gaziosmanpasa Research and Education Hospital · NCT07459413 · Data updated 2026-11-12
This trial will test whether drinking water works as well as intravenous saline to prevent contrast-related kidney injury in adults with reduced kidney function who need a contrast CT in the emergency department.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 198 (estimated) |
| Sponsor | Gaziosmanpasa Research and Education Hospital Government |
| Locations | 1 site (Istanbul, Gaziosmanpasa) |
| Status | Recruiting |
| Started | November 7, 2025 |
| Main results expected | November 7, 2026 |
| Study ends | December 7, 2026 |
| Registry record updated | March 9, 2026 |
| Trial ID | NCT07459413 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with an eGFR between 15 and 59 mL/min/1.73 m² who need a contrast-enhanced CT in the ED, can safely drink fluids, and give informed consent are ideal candidates.
✕Probably not a fit
Patients on dialysis or with eGFR <15, pregnant people, those with decompensated heart failure, recent contrast exposure within 72 hours, known iodinated contrast allergy, or who cannot tolerate oral intake are excluded and unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with an estimated GFR of 15–59 mL/min/1.73 m² who present to a single emergency department for contrast-enhanced CT and can tolerate oral intake are screened and consented. Eligible participants have their ability to take fluids by mouth confirmed, then are randomized to either oral hydration (water) or intravenous 0.9% saline before or around the time of contrast exposure. Kidney function is monitored after imaging to detect contrast-associated acute kidney injury, and participants are followed for the planned study interval. The trial is conducted at Gaziosmanpasa Training and Research Hospital in Istanbul between November 7, 2025 and December 7, 2026.
Why it matters
Potential benefit: If successful, the trial could offer a simpler, lower-cost way to protect at-risk patients’ kidneys and reduce the need for IV lines and hospital resources.
How similar studies have gone: Similar comparisons of oral versus IV hydration have been performed in outpatient imaging with mixed results, and high-quality randomized data specifically in the emergency-department setting remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and older. * Patients with an estimated Glomerular Filtration Rate (eGFR) between 15-59 mL/min/1.73 m². * Patients undergoing contrast-enhanced computed tomography (CT) in the emergency department. * Patients who have provided written informed consent. Exclusion Criteria: * Pregnant women. * Patients with end-stage renal disease (ESRD) receiving dialysis or those with an eGFR \<15 mL/min/1.73 m². * Patients presenting with decompensated heart failure. * Patients with a known allergy to iodinated contrast media. * Patients with contrast media exposure within the last 72 hours. * Patients for whom oral intake is contraindicated or who cannot tolerate oral intake
Where it's running
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Gaziosmanpasa Training and Research Hospital
Istanbul, Gaziosmanpasa, Turkey (Türkiye) Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.