Using aspirin to help women recover from severe preeclampsia after childbirth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of low-dose aspirin on the recovery of women who have experienced severe preeclampsia during childbirth. The hypothesis is that aspirin will reduce levels of a protein called sFlt-1, which is linked to the condition, and help normalize blood pressure more quickly. Participants will take aspirin for the first week postpartum to assess its impact on their recovery. The study aims to address the lack of therapies targeting the underlying causes of postpartum preeclampsia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Preeclampsia with severe features diagnosed during delivery admission, as defined by ACOG criteria.
* Pre- and postnatal care provided by the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic.

Exclusion Criteria:

* Patient age \<18 years old
* Non-English or Non-Spanish speaking
* Chronic hypertension diagnosed before 20 weeks' gestation
* Known allergy, prior adverse reaction, or any medical condition in which aspirin is contraindicated (nasal polyps, gastric or duodenal ulcers, history of gastrointestinal bleeding, severe hepatic dysfunction)
* Aspirin prescribed postpartum for any other medical condition
* Bleeding disorder
* Breastfeeding an infant with thrombocytopenia

Where it's running

• Miller Children's and Women's Hospital, Long Beach/MemorialCare Long Beach
  Long Beach, California, United States Recruiting

Study contacts

• Principal investigator: Megan C Oakes, MD MSCI — Miller Children's and Women's Hospital, Long Beach/ MemorialCare Medical Center
• Study coordinator: Megan C Oakes, MD MSCI
• Email: moakes2@memorialcare.org
• Phone: 562-997-8510

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  Recruiting Phase 4 University of Chicago · Chicago, Illinois · NCT04479072

• Low-dose aspirin for women with severe preeclampsia after delivery

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  Recruiting Phase 2 Columbia University · New York, New York · NCT03667326

• Nifedipine and Enalapril vs Nifedipine and Labetalol for Postpartum Hypertension

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  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07363343

• Postpartum Preeclampsia Early Detection and Treatment in Nepal: A Pilot Study

  This pilot study tests whether using sFlt-1/PlGF biomarker testing before delivery can predict postpartum preeclampsia and whether an early monitoring and treatment bundle helps high-risk, postpartum patients.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin and 1 other locations · NCT07185204

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.