Using aspirin to help women recover from severe preeclampsia after childbirth
Acetylsalicylic Acid for Postpartum Preeclampsia: A Pilot Randomized Trial
PHASE2 · MemorialCare Health System · NCT05924971
This study tests if taking low-dose aspirin for a week after childbirth can help women recover faster from severe preeclampsia.
Quick facts
| Phase | PHASE2 |
|---|---|
| Study type | Interventional |
| Enrollment | 86 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | MemorialCare Health System (other) |
| Locations | 1 site (Long Beach, California) |
| Trial ID | NCT05924971 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of low-dose aspirin on the recovery of women who have experienced severe preeclampsia during childbirth. The hypothesis is that aspirin will reduce levels of a protein called sFlt-1, which is linked to the condition, and help normalize blood pressure more quickly. Participants will take aspirin for the first week postpartum to assess its impact on their recovery. The study aims to address the lack of therapies targeting the underlying causes of postpartum preeclampsia.
Who should consider this trial
Good fit: Ideal candidates are women diagnosed with severe preeclampsia during delivery who are receiving care from the specified medical facilities.
Not a fit: Patients under 18 years old, those with chronic hypertension prior to pregnancy, or those with contraindications to aspirin will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve recovery outcomes for women suffering from postpartum preeclampsia.
How similar studies have performed: While the approach of using aspirin in this context is novel, previous studies have shown aspirin's effectiveness in other pregnancy-related conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Preeclampsia with severe features diagnosed during delivery admission, as defined by ACOG criteria. * Pre- and postnatal care provided by the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic. Exclusion Criteria: * Patient age \<18 years old * Non-English or Non-Spanish speaking * Chronic hypertension diagnosed before 20 weeks' gestation * Known allergy, prior adverse reaction, or any medical condition in which aspirin is contraindicated (nasal polyps, gastric or duodenal ulcers, history of gastrointestinal bleeding, severe hepatic dysfunction) * Aspirin prescribed postpartum for any other medical condition * Bleeding disorder * Breastfeeding an infant with thrombocytopenia
Where this trial is running
Long Beach, California
- Miller Children's and Women's Hospital, Long Beach/MemorialCare Long Beach — Long Beach, California, United States (RECRUITING)
Study contacts
- Principal investigator: Megan C Oakes, MD MSCI — Miller Children's and Women's Hospital, Long Beach/ MemorialCare Medical Center
- Study coordinator: Megan C Oakes, MD MSCI
- Email: moakes2@memorialcare.org
- Phone: 562-997-8510
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Preeclampsia Postpartum, Preeclampsia, Postpartum, Aspirin, sFlt-1