Using Aprepitant to Prevent Nausea in Children After Scoliosis Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of Aprepitant in reducing postoperative nausea and vomiting (PONV) in children undergoing surgery for scoliosis. It is a prospective, randomized, controlled trial that compares Aprepitant with a placebo as an addition to standard multimodal therapy. The primary focus is on the need for anti-nausea rescue medication after surgery, while secondary outcomes include various postoperative symptoms and adverse events. The study aims to provide insights into improving recovery experiences for pediatric patients undergoing spinal fusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Posterior Spinal Instrumentation and Fusion (PSIF) for idiopathic scoliosis
* The fusion must include at least 6 vertebral levels.
* Children greater than or equal to 8 years old, and less than 19 years old on the day of surgery
* Weight \> 40kg - for ease of pharmacy preparation (PONV dose 1mg per kg to max 40mg)

Exclusion Criteria:

* Patient/ Parent refusal
* Hypersensitivity to Aprepitant or any ingredient in the formulation or oral solution. (previous allergy or adverse reaction to Aprepitant)
* Developmental delay as reported by parents
* Pregnant - Pregnancy test done as standard of care pre-operative
* Severe systemic disease ASA classification III or greater
* Concurrent use of any medication with severe interaction with Aprepitant as outlined in product monograph.
* Neuromuscular or congenital scoliosis
* Inability to take PO medications

Where it's running

• IWK Health Sciences Center
  Halifax, Nova Scotia, Canada Recruiting

Study contacts

• Principal investigator: Mathew Kiberd, MD — IWK Health Centre
• Study coordinator: Mathew Kiberd, MD
• Email: mathew.kiberd@iwk.nshealth.ca
• Phone: 7789841329

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.