Using antibiotics to prevent infections after groin hernia surgery in high-risk patients
The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients: A Randomized Control Trial.
This study tests if giving antibiotics before groin hernia surgery can help high-risk patients avoid infections after their operation.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Aleppo Academic / other |
| Locations | 1 site (Aleppo) |
| Trial ID | NCT06576154 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of antibiotic prophylaxis in reducing wound infection rates following open repair of primary elective groin hernias in high-risk patients. It is a randomized controlled trial where participants will be divided into two groups: one receiving cefazolin as antibiotic prophylaxis and the other receiving standard care without antibiotics. The primary outcome will be the incidence of postoperative wound infections in both groups, providing insights into the role of antibiotics in surgical recovery for vulnerable populations.
Who should consider this trial
Good fit: Ideal candidates include elderly patients over 60, those with diabetes, obese patients with a BMI over 35, immunocompromised individuals, or patients classified as ASA physical status 2 or higher.
Not a fit: Patients who are non-cooperative for regular follow-up or do not meet the inclusion criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce the rate of wound infections in high-risk patients undergoing groin hernia surgery.
How similar studies have performed: Previous studies have shown that antibiotic prophylaxis can effectively reduce infection rates in surgical settings, suggesting a positive outlook for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Volunteer to participate in the study. * Elderly patients aged over 60 years. * Patients with Diabetes. * Or obese patients with a BMI greater than 35. * Or immunocompromised patients. * Or American Society of Anesthesiologists (ASA) physical status classification 2 or more, with a history of more than 10 years. Exclusion Criteria: * Non-cooperative patients for regular follow-up. * Therapeutic Indication for.
Where this trial is running
Aleppo
- Aleppo University Hospital — Aleppo, Syria (Recruiting)
Study contacts
- Study coordinator: Mohammad H Nabhan, M.D
- Email: m.hassannabhan@gmail.com
- Phone: +963956768862
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.