Using airway resistance changes to guide suctioning for ventilated patients
Official title: Mechanisms of Dynamic Airway Resistance Monitoring and Machine Learning for Assessing Pulmonary Inflammation and Guiding Sputum Suction in Mechanically Ventilated Patients
Run by Affiliated Hospital of Nantong University · NCT07375667 · Data updated 2026-11-12
This study will test whether monitoring airway viscous resistance from ventilator waveforms can help time sputum suctioning for patients on mechanical ventilation with ARDS, AECOPD, or severe pneumonia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 258 (estimated) |
| Sponsor | Affiliated Hospital of Nantong University Academic / other |
| Locations | 3 sites (Bengbu, Anhui and 2 other locations) |
| Status | Recruiting |
| Started | October 30, 2025 |
| Main results expected | December 30, 2028 |
| Study ends | December 30, 2029 |
| Registry record updated | January 29, 2026 |
| Trial ID | NCT07375667 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Patients on invasive mechanical ventilation for ARDS, acute exacerbation of COPD, or severe pneumonia who meet ICU clinical criteria are the intended participants.
✕Probably not a fit
Patients with multiple organ failure or active multi-site bleeding (who are excluded) or those not on mechanical ventilation are unlikely to benefit from the intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial continuously derives airway viscous resistance metrics from ventilator waveforms and compares dynamic patterns to conventional suctioning schedules. It correlates changes in viscous resistance with inflammatory biomarkers over time to explore temporal relationships. The team aims to establish reference thresholds for special populations and to validate the feasibility and reliability of resistance-based monitoring. Data will be collected at multiple tertiary hospitals in China and used to inform optimal suctioning timing.
Why it matters
Potential benefit: If successful, this approach could reduce pulmonary inflammation and complications by prompting suctioning at more precise times, potentially lowering ventilator-associated pneumonia rates and improving recovery.
How similar studies have gone: Previous work supports that timely suctioning improves outcomes, but using ventilator-derived viscous resistance and machine-learning guidance is a novel approach with limited prior clinical validation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of Acute Respiratory Distress Syndrome (ARDS) * Clinical diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) * Clinical diagnosis of Severe pneumonia Exclusion Criteria: * Clinical diagnosis of multiple organ failure; * Clinical diagnosis of multiple organ bleeding;
Where it's running
-
The First Affiliated Hospital of Bengbu Medical University
Bengbu, Anhui, China Recruiting -
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China Recruiting -
the Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Study coordinator: Hong-lei Wu Nursing Department, MS
- Email: wu_honglei@163.com
- Phone: +8613862749927
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This study tests whether signs of innate immune immunoparalysis in adults on ventilators are linked to developing ventilator-associated pneumonia (VAP).
-
Combined mPCR and algorithm-based therapy to optimize early antibiotics in VAP
This trial tests whether adding a broad respiratory mPCR test and a local-epidemiology algorithm helps doctors choose better initial antibiotics within 24 hours for adults with ventilator-associated pneumonia.
-
Two Oral Care Methods for Mechanically Ventilated Adults
This trial tests whether a pediatric toothbrush or a foam swab for oral care affects oral bacteria and the risk of ventilator-associated pneumonia in adults on mechanical ventilation.
-
Aztreonam‑avibactam for MBL-producing CRE infections in hospitalized adults
This study will see if aztreonam‑avibactam helps hospitalized adults with complicated intra‑abdominal infections or hospital/ventilator‑associated pneumonia caused by MBL-producing CRE.
-
Early detection of ventilator-associated pneumonia in critically ill children using microbial and immune signatures.
This project will test whether combining microbial genomic data and a child's immune-response signals can detect ventilator-associated pneumonia earlier in critically ill children on mechanical ventilation.
-
Inhaled colistin to prevent pneumonia in ventilated patients
This study is testing if inhaled colistin can help prevent pneumonia in patients on ventilators who are at high risk for infections.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.