Two Oral Care Methods for Mechanically Ventilated Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-centre, parallel-group randomized trial compares two oral care methods in mechanically ventilated adult ICU patients. Over five days, all participants receive chlorhexidine and saline as needed, with oral care frequency guided by OCAS-ICP assessments. Oropharyngeal swabs collected on days 1 and 6 will assess shifts in bacterial and fungal colonization, including Staphylococcus, Pseudomonas, Acinetobacter, and Candida species. The study aims to determine if the method of oral care influences microbial colonization and VAP development.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who have been on invasive mechanical ventilation for 24 hours or less
* Patients who provide informed consent through their legal representative or themselves if capable.
* Patients with no prior oral surgery, no head or neck trauma, and no contraindications to oral care.
* Patients aged 18 years or older.

Exclusion Criteria:

* Patients under 18 years of age.
* Patients who have been on invasive mechanical ventilation for more than 24 hours before enrollment.
* Patients with oral surgical procedures or trauma to the head or neck.
* Patients with contraindications to oral care, such as severe oral bleeding, mucositis, or active oral infections.
* Patients or legal representatives who do not provide informed consent.

Where it's running

• Zonguldak Atatürk State Hospital, Ministry of Health, Türkiye
  Zonguldak, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Gulten OKUROĞLU, Assoc.Prof — Marmara University
• Study coordinator: Ayse AYDIN, PhD Cand.
• Email: ayseelaaydin@outlook.com
• Phone: + 905314099989

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.