Using AI to classify rectal cancer during surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to validate the use of artificial intelligence in classifying rectal cancer and polyps during real-time surgical procedures. It focuses on patients with rectal polyps larger than 2cm, which pose significant diagnostic challenges due to the risk of containing cancer. The study will assess the effectiveness of AI in improving the accuracy of pre-surgical classifications, potentially leading to better treatment decisions and outcomes. Participants will include those undergoing surgical intervention for suspected or confirmed rectal tumors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants with a confirmed or suspected rectal polyp/tumour measuring greater than 2cm undergoing surgical intervention or assessment OR Patients with a known rectal cancer undergoing surgical intervention or assessment, including those post neo adjuvant therapy.
* Participant is willing and able to give informed consent for participation in the study. ● Male or Female, aged 18 years or above.
* Clinically fit for elective intervention

Exclusion Criteria:

* Female participant who is pregnant, lactating or planning pregnancy within three months of the study
* Significant renal or hepatic impairment.
* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study. ● Allergy to intravenous contrast agent or iodides
* Other contraindications to ICG including concurrent use of anticonvulsants, bisulphite containing drugs, methadone and nitrofurantoin.

Where it's running

• Mater Misericordiae University Hospital
  Dublin, Ireland, Ireland Recruiting

Study contacts

• Principal investigator: Ronan Cahill — University College Dublin
• Study coordinator: Alice Moynihan
• Email: alice.moynihan@ucd.ie
• Phone: 353 (0)1 716 4000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Local excision for preserving the rectum in early rectal cancer

  This study is testing if a surgery called local excision can effectively treat early rectal cancer while helping patients keep their rectum.

  Recruiting Fundación de Investigación Biomédica - Hospital Universitario de La Princesa · Madrid · NCT05927584

• Single vs. double stapling and purse-string techniques after rectal cancer surgery

  This trial tests whether using a single-stapling method to join the bowel after rectal cancer surgery results in fewer leaks compared with the double-stapling method.

  Recruiting Alexandria University · Alexandria · NCT07929415

• DEM301 in advanced colorectal cancer: a first-in-human test

  This first-in-human Phase 1 study tests DEM301 in adults with advanced metastatic colorectal cancer to see if it is safe, how it behaves in the body, and whether it shows any signs of activity.

  Recruiting at 2 sites Phase 1 DEM BioPharma, Inc. · Birtinya, Queensland and 1 other locations · NCT07805369

• Rectal cancer registry to track real-world treatments and outcomes

  This registry collects real-world data on how locally advanced rectal cancer is treated in Austria, to see how TNT and dMMR/MSI-H cases are managed and what outcomes occur.

  Recruiting at 2 sites Austrian Breast & Colorectal Cancer Study Group · Wiener Neustadt, Lower Austria and 5 other locations · NCT07780305

• Aerobic exercise and guided imagery for bowel problems after rectal cancer surgery

  This study tests whether a program of aerobic exercise plus guided imagery helps people with low anterior resection syndrome after rectal cancer surgery.

  Recruiting Biruni University · Istanbul · NCT07732894

• Active surveillance vs chemoradiotherapy after local removal of intermediate-risk T1 rectal cancer

  This study tests whether close follow-up alone after local removal of early rectal cancer can match the cancer control of adding chemoradiotherapy, while reducing treatment-related side effects.

  Recruiting at 2 sites Medical University of Gdansk · Limoges and 2 other locations · NCT07669298

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.