Using advanced imaging to better understand solitary bone lesions
Official title: Contribution of MUltiparametric Analysis in Bone Scintigraphy for the Characterisation of Solitary Bone Lesions Whose Malignant Origin Cannot be Excluded on Conventional Imaging
Run by Central Hospital, Nancy, France · NCT05934994 · Data updated 2026-11-12
This study is testing a new imaging technique to see if it can help doctors better understand solitary bone lesions and tell apart harmless ones from cancerous ones, which could reduce the need for unnecessary biopsies.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 68 (estimated) |
| Sponsor | Central Hospital, Nancy, France Academic / other |
| Locations | 1 site (Vandœuvre-lès-Nancy) |
| Status | Recruiting |
| Started | September 11, 2023 |
| Main results expected | December 10, 2026 |
| Study ends | January 10, 2027 |
| Registry record updated | June 25, 2026 |
| Trial ID | NCT05934994 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with indeterminate solitary bone lesions who are facing potential biopsy or excision.
✕Probably not a fit
Patients who are pregnant, have unstable medical conditions, or have known allergies to the radiopharmaceutical used will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of multiparametric analysis using Single Photon Emission Computed Tomography (SPECT-CT) in characterizing solitary bone lesions. The approach involves a three-stage bone scintigraphy process that assesses perfusion, early tissue uptake, and late bone fixation. The goal is to improve the accuracy of diagnosing these lesions, particularly in distinguishing between benign and malignant cases, thereby reducing the need for unnecessary biopsies. By quantifying the intensity of the signal at different stages, the study aims to provide clearer insights into the nature of the lesions.
Why it matters
Potential benefit: If successful, this study could significantly reduce the number of unnecessary biopsies and associated complications for patients with solitary bone lesions.
How similar studies have gone: While the use of SPECT-CT in bone imaging is established, this specific multiparametric analysis approach is novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Person, having received complete information on the organization of the research and having signed the informed consent and: * Age ≥ 18 years old. * Having read and understood the information document. * Affiliated to a social security scheme. * Patient with an indeterminate solitary bone lesion on conventional imaging, for which an indication for biopsy +/- excision is planned. Exclusion Criteria: * Pregnant woman or woman of childbearing age and without contraceptive means or nursing mother. * Unstable medical condition and/or inability to remain still during recordings. * Known allergy to one of the components of the radiopharmaceutical technetium-99m-Technescan HDP (product required to perform the bone scan). * Person referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code. * Persons deprived of their liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1, L. 3213-1
Where it's running
-
CHRU Nancy
Vandœuvre-lès-Nancy, France Recruiting
Study contacts
- Study coordinator: ACHRAF BAHLOUL, MD, MSc
- Email: a.bahloul@chru-nancy.fr
- Phone: 383154003
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.