Using advanced CT imaging to assess rectal cancer growth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effectiveness of a photon counting detector CT scanner (PCD-CT) in determining the growth of rectal cancer compared to traditional MRI methods. Adult patients with confirmed rectal cancer who are referred for staging will undergo imaging with PCD-CT alongside standard contrast-enhanced CT and MRI. The goal is to assess whether PCD-CT can provide equal or superior imaging results for managing rectal cancer. The study aims to improve the accuracy of local staging in rectal cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients 18 to 99 years of age
* Patients with proven rectal cancer clinically referred for staging pelvic MRI and contrast-enhanced CT of the abdomen and pelvis (for evaluation of liver and peritoneal disease)
* Endoscopic or imaging report that tumor is 2 cm or larger
* Patients who are able and willing to sign the informed consent
* Negative pregnancy test if subject is of child-bearing age (females of child-bearing potential will be screened for pregnancy using a urine pregnancy test, which will be administered by the unit study coordinator at no cost to the patient)

Exclusion Criteria:

* Minors less than 18 years old
* Patient unable to provide written informed consent
* Pregnancy
* Estimated Glomerular Filtration Rate (eGFR) ≤ 60
* History of prior moderate or severe contrast reaction including unresponsiveness, severe respiratory distress, convulsions, arrhythmia, cardiopulmonary distress, progressive angioedema, laryngeal edema, dyspnea, bronchospasm, symptomatic tachycardia, symptomatic bradycardia, hypotension, hypertensive crisis
* Any history of premedication prior to iodinated contrast
* Bilateral hip replacement/prosthesis
* Patients that consent to participation but do not undergo their clinically indicated MRI scanning for any reason (e.g., bad IV, infiltration, reaction, change in indication)

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Joel G. Fletcher, MD — Mayo Clinic in Rochester
• Study coordinator: Clinical Trials Referral Office
• Email: mayocliniccancerstudies@mayo.edu
• Phone: 855-776-0015

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.