Using Adebrelimab with chemotherapy for early-stage small cell lung cancer

A Multicenter Randomized Controlled Trial of Neoadjuvant Adebrelimab Combined With Chemotherapy for Resectable Small Cell Lung Cancer (SCLC)

This study is testing if adding Adebrelimab to chemotherapy helps people with early-stage small cell lung cancer do better before surgery compared to just chemotherapy alone.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 104 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Tang-Du Hospital (Academic / other)
• Drugs / interventions: chemotherapy, radiation, prednisone, Adebrelimab
• Locations: 1 site (Xi'an, Shannxi)
• Trial ID: NCT06485544 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness and safety of Adebrelimab combined with chemotherapy (etoposide and platinum-based therapy) as a neoadjuvant treatment for patients with resectable stage I-IIIB small cell lung cancer (SCLC). The study is randomized and open-label, enrolling 104 patients who will be assigned to receive either the combination treatment or chemotherapy alone. Participants will undergo three cycles of treatment followed by a break before surgery, with monitoring for effectiveness and safety throughout the trial. The primary objective is to assess the outcomes of the treatment regimen in this patient population.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 to 75 with resectable stage I-IIIB small cell lung cancer and no prior treatment.

Not a fit: Patients with metastatic small cell lung cancer or those who have received prior treatment for their cancer may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment approach could improve surgical outcomes and overall survival for patients with early-stage small cell lung cancer.

How similar studies have performed: Other studies have shown promise with similar neoadjuvant approaches in small cell lung cancer, but this specific combination is being explored for the first time.

Eligibility criteria

Inclusion Criteria:

1. Age between 18 and 75 years, inclusive, with no restriction on gender.
2. ECOG performance status of 0-1.
3. Histologically or cytologically confirmed diagnosis of small cell lung cancer (SCLC).
4. According to the 8th edition of AJCC staging, participants must have resectable or potentially resectable stage I-IIIB (T1-4N0-2M0) SCLC.
5. Measurable lesions (tumor lesions with a CT scan long axis ≥10 mm, lymph node lesions with a CT scan short axis ≥10 mm).
6. Initial diagnosis of small cell lung cancer without prior treatment with radiation, chemotherapy, traditional Chinese medicine, surgery, or targeted therapy.
7. Various imaging examinations including PET-CT, enhanced CT or ultrasound of the chest and abdomen, MRI of the head, and bone scan confirm no metastatic lesions.
8. Participants must have sufficient cardiopulmonary function to tolerate planned lung resection surgery.
9. No contraindications to immune checkpoint inhibitor (ICI) use based on laboratory tests.
10. Normal organ function, as defined by the following criteria:

(1) Hematological criteria (within 14 days without blood transfusion, hematopoietic factors, or correcting medications):

1. ANC ≥ 1.5 × 10\^9/L;
2. PLT ≥ 100 × 10\^9/L;
3. Hb ≥ 90 g/L; (2) Biochemical criteria:

a. TBIL ≤ 1.5 × ULN; b. ALT, AST ≤ 2.5 × ULN (if abnormal liver function due to liver metastasis, ≤ 5 × ULN); c. Serum creatinine (sCr) ≤ 1.5 × ULN, estimated glomerular filtration rate (eGFR) ≥ 50 mL/min (Cockcroft-Gault formula); (3) Coagulation function: INR ≤ 1.5 × ULN and APTT ≤ 1.5 × ULN. 11. Female participants of childbearing potential must have a negative serum pregnancy test within 3 days before starting study medication and agree to use a medically accepted method of highly effective contraception during the study and for 3 months after the last dose of study drug (e.g., intrauterine device, contraceptive pills, or condoms). Male participants with female partners of childbearing potential must have undergone surgical sterilization or agree to use effective contraception during the study and for 3 months after the last dose of study drug.

12\. Participants must voluntarily consent to participate in this study, sign an informed consent form, demonstrate good compliance, and agree to follow-up visits.

Exclusion Criteria:

1. Central nervous system metastasis.
2. History of any active autoimmune disease or autoimmune disease (including but not limited to moderate or severe interstitial lung disease, uveitis, colitis, hepatitis, hypophysitis, vasculitis, myocarditis, nephritis, hyperthyroidism, hypothyroidism \[patients controlled by hormone replacement therapy may be included\]); patients with vitiligo or childhood asthma completely resolved without adult intervention may be included; patients requiring bronchodilators for medical intervention are excluded.
3. Congenital or acquired immunodeficiency, such as HIV infection, active hepatitis B (HBV DNA ≥ 500 IU/mL), hepatitis C (HCV antibody positive with HCV-RNA above the lower limit of detection by analytical methods), or co-infection of hepatitis B and C, active pulmonary tuberculosis.
4. Use of immunosuppressive drugs within 14 days prior to the first administration of the study drug, excluding nasal and inhaled corticosteroids or physiological doses of systemic steroid hormones (i.e., no more than 10 mg/day of prednisone or its equivalent).
5. Vaccination with live attenuated vaccines within 4 weeks before the first administration or planned during the study period.
6. Any other malignancy within the past 3 years.
7. Evidence of past or present pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-induced pneumonia, or severely impaired lung function.
8. Uncontrolled hypertension.
9. Grade II or higher myocardial ischemia or myocardial infarction, uncontrolled arrhythmias (including QTc interval ≥450 ms for males and ≥470 ms for females). According to NYHA standards, Class III-IV heart failure, or left ventricular ejection fraction (LVEF) \< 50% by cardiac ultrasound, myocardial infarction within 6 months before enrollment, NYHA Class II or higher heart failure, uncontrolled angina, uncontrolled severe ventricular arrhythmias, clinically significant pericardial disease, or electrocardiogram (ECG) indicating acute ischemia or active conduction system abnormalities.
10. Severe infection within 4 weeks before the first administration (e.g., requiring intravenous antibiotics, antifungals, or antivirals), or unexplained fever \> 38.5°C during screening/first administration.
11. History of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation.
12. Pregnant or breastfeeding women; patients of childbearing potential unwilling or unable to use effective contraception.
13. Known allergic reaction, hypersensitivity, or intolerance to SHR-1316, etoposide, cisplatin, or their excipients.
14. Participation in another clinical study or less than 4 weeks since the end (last dose) of a previous clinical study, or less than 5 half-lives of the study drug.
15. Known history of substance abuse, alcohol abuse, or drug addiction.
16. Any condition that the investigator believes may compromise the safety of the participant or the participant's ability to meet or follow study requirements.

Where this trial is running

Xi'an, Shannxi

• Tangdu Hospital Affiliated to the Fourth Military Medical University — Xi'an, Shannxi, China (Recruiting)

Study contacts

• Study coordinator: Xiaolong Yan, Dr

Conditions Small Cell Lung Cancer; SCLC; Adebrelimab; Neoadjuvant; Chemotherapy