Using Acostream for treating high-risk pulmonary embolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This registry evaluates the safety and feasibility of catheter-directed aspiration using Acostream in patients with high-risk and intermediate-high-risk pulmonary embolism. It is a prospective, multicenter, observational study involving 130 patients across up to seven sites in China. The primary focus is on the efficacy and safety of pulmonary thrombus removal, measured by various clinical outcomes including reduction of ventricular strain and overall clinical improvement. Secondary endpoints will assess total mortality rates and complications associated with the procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18≤Age≤85
* Clinical symptoms and presentation consistent with pulmonary embolism (PE).
* PE symptoms duration ≤ 14 days.
* High risk PE patients with absolute contraindications to systemic thrombolysis or its failure (refractory circulatory collapse) not eligible for surgical embolectomy.
* Intermediate-high risk PE patients with right ventricle dysfunction (right ventricle/ left ventricle \>0.9) confirmed by computed tomography pulmonary angiography or transthoracic echocardiography.

Exclusion Criteria:

* Pregnancy.
* Refusal to sign the informed consent form.
* Presence of intracardiac thrombus.
* Presence of chronic left heart failure with an ejection fraction lower than 30% Diagnosed thrombophilia.
* History of severe or chronic pulmonary hypertension.
* Serum creatinine level higher than 1.8 mg/dl.
* Known serious and uncontrolled sensitivity to radiographic agents.

Where it's running

• Renji Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Qihong Ni
• Email: niqihong1989@163.com
• Phone: 15801900772

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ultrasound-guided catheter clot-dissolving treatment for adults with moderate-to-high risk pulmonary embolism

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  Recruiting Johannes Gutenberg University Mainz · Mainz, Rhineland-Palatinate · NCT02156401

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.