Using a technique to prevent kidney injury after heart surgery
Application of Controlled Low Central Venous Pressure Technique in Early Intervention of Cardiac Surgery-associated Acute Kidney Injury
This study is testing a new method during heart surgery to see if it can help prevent kidney damage in patients without causing problems with their thinking afterwards.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Nanjing First Hospital, Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT05855954 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of the Controlled Low Central Venous Pressure (CLCVP) technique in reducing the incidence of acute kidney injury (AKI) following cardiac surgery. The study aims to determine if this technique can lower venous congestion and enhance renal perfusion pressure without increasing the risk of postoperative cognitive dysfunction. Participants will be monitored after surgery, with specific interventions applied based on their central venous pressure levels. The trial focuses on patients undergoing various types of cardiac surgeries, including coronary artery bypass grafting and heart valve surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are scheduled for cardiac surgery.
Not a fit: Patients with pre-existing renal insufficiency or those requiring dialysis prior to surgery will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the occurrence of acute kidney injury in patients undergoing cardiac surgery, leading to better postoperative outcomes.
How similar studies have performed: While the CLCVP technique has been widely used in other surgical settings, its application in cardiac surgery is less explored, making this study a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and older, who underwent cardiac surgery (coronary artery bypass grafting (CABG), heart valve surgery, heart transplant or surgical excision of intracardiac myxoma) were eligible for analyses. Exclusion Criteria: * pre-existing renal insufficiency defined by presence of abnormal preoperative serum creatinine ≥ 133 μmol/L and/or preoperative diagnosis of renal insufficiency within 6 months' preoperative period. * patients with preoperative dialysis dependence within 60 days before surgery, off-pump heart surgery, prior kidney transplantation, pregnancy, as well as those under drug therapy with nitroglycerin were excluded.
Where this trial is running
Nanjing, Jiangsu
- Nanjing First Hospital — Nanjing, Jiangsu, China (Recruiting)
Study contacts
- Study coordinator: Yali Ge, Doctor
- Email: ge_yl@163.com
- Phone: China+025-52271064
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.