Underwater Mucosal Resection vs. Endoscopic Submucosal Dissection for Small Rectal Neuroendocrine Tumors
Official title: Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors: A Prospective, Multicenter, Non-inferiority Trial
Run by Nanfang Hospital, Southern Medical University · NCT07759960 · Data updated 2026-11-12
This study tests whether underwater endoscopic mucosal resection can match or beat endoscopic submucosal dissection for removing small rectal neuroendocrine tumors in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 174 (estimated) |
| Sponsor | Nanfang Hospital, Southern Medical University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | April 14, 2026 |
| Main results expected | October 2029 |
| Study ends | December 2029 |
| Registry record updated | August 12, 2026 |
| Trial ID | NCT07759960 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 with suspected or confirmed rectal NET up to 10 mm, suitable for either UEMR or ESD, and able to provide informed consent.
✕Probably not a fit
Patients with larger tumors, lymph node or distant metastasis, or who cannot tolerate endoscopic procedures may not benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, multicenter, non-inferiority randomized trial comparing two endoscopic techniques for treating small rectal neuroendocrine tumors. Ten centers in China will enroll eligible adults with rectal NETs measuring 10 mm or less and randomize them to UEMR or ESD. The study will assess efficacy and safety outcomes to determine if UEMR is non-inferior to ESD. Results could inform best-practice guidelines for minimally invasive treatment of small rectal NETs.
Why it matters
Potential benefit: If successful, patients may benefit from a simpler or safer endoscopic option with comparable tumor removal effectiveness.
How similar studies have gone: Prior reports show both UEMR and ESD can treat small rectal NETs, but direct comparative proof is limited, making this trial novel in its non-inferiority design.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age from 18 to 75 years; 2. With a high suspicion or evidence of rectal NET assessed using EUS, CT scan or colonoscopy; 3. With tumor size ≤10 mm assessed by colonoscopy or EUS; 4. Plan to receive UEMR or ESD treatment and provide written informed consent. Exclusion Criteria: 1. Unable to tolerate ESD or UEMR as assessed by the research team; 2. Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation; 3. Rectal NET with lymph node metastasis or distant metastasis; 4. Received resection of rectal neuroendocrine tumor by other surgical procedures; 5. Multiple rectal neuroendocrine tumors; 6. Vulnerable groups such as pregnant women or patients with mental disorders; 7. Poor compliance, unable to cooperate with treatment.
Where it's running
-
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Zelong Han, MD
- Email: hanzelong2025@163.com
- Phone: +86 20-6278-7385
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.