Understanding the mechanisms of type 1 diabetes in young people
Mechanisms of Type 1 Diabetes Endophenotypes, by Cluster Analysis
This study looks at how type 1 diabetes develops in kids and young adults by examining their health data to better understand the disease and its risks.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 0 Years to 25 Years |
| Sex | All |
| Sponsor | Pediatric Clinical Research Platform Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (Geneva) |
| Trial ID | NCT05764850 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the underlying mechanisms of type 1 diabetes in children and young adults through cluster analysis. By integrating clinical, laboratory, genetic, transcriptomic, and metabolomic data from a well-characterized cohort, the study seeks to uncover insights into the disease's progression and associated cardiovascular risks. The research will involve genome sequencing to enhance understanding of genetic predispositions to type 1 diabetes.
Who should consider this trial
Good fit: Ideal candidates include children and young adults aged 0 to 25 years diagnosed with type 1 diabetes.
Not a fit: Patients over 25 years old or those with conditions affecting metabolic control may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of type 1 diabetes in young patients.
How similar studies have performed: Other studies have shown promise in understanding type 1 diabetes mechanisms, but this approach may provide novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria (Type 1 Diabetic patients): * Informed consent as documented by signature * Patient's age: between 0 and 25 years old. * Children, adolescents, and young adult patients followed in diabetology. Exclusion Criteria (Type 1 Diabetic patients): * No exclusion criteria Inclusion Criteria (Controls): * Informed consent as documented by signature * Patient's age: 25 less than 6 years of age and 25 between 6 and 25 years old. * Healthy patient Exclusion Criteria (Controls): * Patient receiving treatment affecting metabolic control (ex: systemic corticoids, beta blocker, immunotherapy etc.) * Concomitant disease that may affect the analysis of the results (ex: cancer, active autoimmune disease requiring treatment)
Where this trial is running
Geneva
- University Hospital of Geneva — Geneva, Switzerland (Recruiting)
Study contacts
- Principal investigator: Valerie VS Schwitzgebel, MD — University Hospital of Geneva / University of Geneva
- Study coordinator: Valerie VS Schwitzgebel, MD
- Email: valerie.schwitzgebel@unige.ch
- Phone: +41 22 372 45 90
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.