Understanding risk factors for Parkinson's disease through participant reports

Parkinson's Progression Markers Initiative Online Study (PPMI Online)

Observational Michael J. Fox Foundation for Parkinson's Research · NCT05065060

This study is trying to find out what factors might increase the risk of getting Parkinson's disease by gathering information from people with and without the condition.

Quick facts

Study typeObservational
Enrollment500000 (estimated)
Ages18 Years and up
SexAll
SponsorMichael J. Fox Foundation for Parkinson's Research Academic / other
Locations1 site (San Francisco, California)
Trial IDNCT05065060 on ClinicalTrials.gov

What this trial studies

The Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study that collects information from individuals with and without Parkinson's disease to identify risk and predictive factors associated with the condition. This initiative is part of a larger program aimed at discovering markers of disease progression, which can be utilized in clinical trials for therapies targeting the reduction of Parkinson's disability. Participants may be involved in various related protocols, enhancing the breadth of data collected for analysis.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older, both those diagnosed with Parkinson's disease and those without a diagnosis.

Not a fit: Patients who are under 18 years old or those with other neurodegenerative disorders unrelated to Parkinson's disease may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and early identification of Parkinson's disease, potentially guiding preventive strategies and treatments.

How similar studies have performed: Other studies focusing on participant-reported outcomes in neurodegenerative diseases have shown promise, indicating that this approach could yield valuable insights.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Parkinson Disease (PD) Participants:

  * Male or female age 18 years or older.
  * Has received a diagnosis of Parkinson's disease

Participants without PD:

* Male or female age 18 years or older.
* Has not received a diagnosis of Parkinson's disease

Where this trial is running

San Francisco, California

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Parkinson DiseaseParkinsonNeurodegenerative DisorderProdromalAt RiskParticipant Reported Outcomes
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.