Understanding risk factors for chronic kidney disease linked to metabolic diseases
Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases
This study is trying to find out how conditions like high blood pressure, diabetes, and obesity can lead to kidney problems in people with chronic kidney disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Peking Union Medical College Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT05476627 on ClinicalTrials.gov |
What this trial studies
This observational study aims to build a cohort of patients suffering from chronic kidney disease (CKD) caused by metabolic diseases such as hypertension, diabetes, hyperuricemia, and obesity. It will investigate the common pathophysiological mechanisms leading to renal injury, including the activation of the Renin-Angiotensin-Aldosterone System and oxidative stress. By identifying risk factors and potential biomarkers, the study seeks to enhance understanding of CKD progression in the context of metabolic disorders.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 80 diagnosed with metabolic diseases.
Not a fit: Patients with primary and secondary glomerular diseases or other significant renal comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and management strategies for chronic kidney disease in patients with metabolic diseases.
How similar studies have performed: While there have been studies on chronic kidney disease and metabolic diseases, this specific multiomics approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The diagnosis of metabolic diseases were confirmed; * Be able to understand the process of the research; * Volunteer for participation and be able to sign the informed consent. Exclusion Criteria: * Age \<18 yrs or \>80yrs; * Patients with primary and secondary glomerular diseases * Patients with other comorbidities that could affect the volume or the components of the kidney, such as renal cysts, polycystic kidney disease, medullary sponge kidney, hydronephrosis, renal artery stenosis, renal vein thrombosis and/or renal tumors; * Contraindications for MRI examination; * Pregnant or lactation patients; * Patients with unstable vital signs, failure of other organs or dysphoria.
Where this trial is running
Beijing, Beijing Municipality
- Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Limeng Chen — Peking Union Medical College Hospital
- Study coordinator: Yan Liu
- Email: liuyanpumch@163.com
- Phone: +86-15811568692
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.