Understanding risk factors for chronic kidney disease in Malawi
Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi to Inform Interventions for Earlier Detection and Prevention (Impso Study)
This study looks at the causes and risks of chronic kidney disease in Malawi to help improve prevention and treatment strategies for people affected by it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Liverpool School of Tropical Medicine Academic / other |
| Locations | 1 site (Chilumba, Karonga) |
| Trial ID | NCT06312072 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify the mortality associated with chronic kidney disease (CKD) and the risk factors contributing to its development and progression in Malawi. By analyzing data from a demographic surveillance survey and a long-term conditions survey, the study seeks to fill knowledge gaps regarding CKD in low-income settings. The research will focus on both traditional and non-traditional risk factors, including the impact of other long-term conditions such as hypertension and HIV. The findings could inform public health strategies to prevent and manage CKD in Malawi.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older living in specific demographic surveillance sites in Malawi with available serum samples.
Not a fit: Patients under 18 years old or those not residing in the designated study areas will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and cost-effective interventions for chronic kidney disease in Malawi.
How similar studies have performed: While there is limited longitudinal research on CKD in Malawi, similar studies in other low-income countries have highlighted the importance of understanding risk factors for chronic diseases, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Aim 1, Objective 1 (survival analysis): Inclusion Criteria: * Adult ≥ 18 years at time of participation in 2013-16 NCD survey * Living in one of the demographic surveillance sites (Chilumba, Karonga or Lilongwe area 25) * Creatinine +/- cystatin C result available from serum sample taken in 2013-16 NCD survey Exclusion Criteria: * Child (age \<18 years) * Not living in one of the study areas Aim 1, Objective 2 (retrospective cohort study) Inclusion criteria: * eGFRcreat ≥60ml/min/1.73m3 at baseline (using creatinine tested on serum sample from 2013-16 survey) * Participated and provided blood (serum) sample in 2022-25 long-term conditions (LTC) survey i.e. individual-level longitudinal paired serum samples available, including consent already given for testing of stored samples in future studies Exclusion Criteria: * Child (age \<18 years) * Not living in one of the study areas * Not consented previously to storage of blood samples and use of samples in future studies Aim 1, Objective 3 Inclusion criteria: As for Objective 1, PLUS: * eGFRcystC \<90ml/min/1.73m3 at baseline (using cystatin C tested on 2013-16 serum sample) * Participated and provided serum sample in 2022-25 long-term conditions (LTC) survey i.e. individual-level longitudinal paired serum samples available * Still alive and living in one of the demographic surveillance sites * Able to provide consent or assent with consent from an appropriate nominated guardian Exlusion criteria: * Declines consent * Unable to consent or assent * Children (\<18 years) * Non-resident in study areas * Acute physical or mental illness * Hospital inpatient * Hospital admission \>24 hours in past 90 days and \<90 days until study end * Currently pregnant
Where this trial is running
Chilumba, Karonga
- Malawi Epidemiology and Intervention Research Unit — Chilumba, Karonga, Malawi (Recruiting)
Study contacts
- Principal investigator: Charlotte Snead, BM BCh — Liverpool School of Tropical Medicine
- Study coordinator: Laurence Tembo
- Email: laurence.tembo@meiru.mw
- Phone: +265 888 348 705
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.