Understanding rebound pain in patients after knee surgery

Rebound Pain and Related Factors in Patients Who Underwent Femoral Nerve Block for Postoperative Pain Control in Total Knee Arthroplasty

Observational Gulhane Training and Research Hospital · NCT05910281

This study looks at how often and why patients feel severe pain after knee surgery, especially after using nerve blocks for pain relief, to help improve pain management for future surgeries.

Quick facts

Study typeObservational
Enrollment150 (estimated)
Ages18 Years to 80 Years
SexAll
SponsorGulhane Training and Research Hospital Government
Locations1 site (Ankara, None Selected)
Trial IDNCT05910281 on ClinicalTrials.gov

What this trial studies

This observational study aims to identify rebound pain and its related factors in patients who have undergone total knee arthroplasty. The focus is on understanding the occurrence of severe pain that can arise after the use of peripheral nerve blocks for pain management. By monitoring patients post-surgery, the study seeks to gather data on the intensity and duration of rebound pain, which typically manifests as a burning sensation. The findings could help improve postoperative pain management strategies for knee surgery patients.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-80 who are scheduled for total knee arthroplasty.

Not a fit: Patients with severe comorbidities, active infections, or neuropsychiatric disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to better pain management protocols for patients undergoing total knee arthroplasty.

How similar studies have performed: While the specific focus on rebound pain in this context may be novel, similar studies on postoperative pain management have shown promising results.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18-80 years older age who underwent total knee arthroplasty

Exclusion Criteria:

* ASA score 4 or \>4
* Active infection
* End stage organ failure
* Pregnancy
* Established diagnosis neuropsychiatric disease ( epilepsy, neuropathy, neuromuscular disease, cerebrovascular disease...)
* Uses of oral corticosteroids

Where this trial is running

Ankara, None Selected

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Postoperative PainPostoperative ComplicationsPostoperative Nausea and Vomiting
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.