Understanding protein levels and blood flow in kidney transplant patients
A Prospective, Observational, Non-interventional, Single-center Study to Analyze the Relationship Between Proteinuria and Renal Perfusion in Renal Transplant Recipients
This study looks at how protein levels in urine relate to blood flow in kidney transplant patients to help improve their care after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University of Erlangen-Nürnberg Medical School Academic / other |
| Locations | 1 site (Erlangen) |
| Trial ID | NCT06051812 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between proteinuria and renal perfusion in patients who are undergoing living donor kidney transplantation. It focuses on differentiating the source of proteinuria, whether from the native kidneys or the transplanted allograft, which is crucial for effective management post-transplant. The study will include patients aged 18 to 75 who have been accepted for transplantation and have a minimum urine output. The findings could enhance understanding of cardiovascular risks associated with proteinuria in this population.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 18 to 75 who are evaluated and accepted for living donor kidney transplantation with adequate urine output.
Not a fit: Patients with unstable health conditions, active substance abuse, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for kidney transplant recipients, potentially reducing cardiovascular risks.
How similar studies have performed: Previous studies have indicated a significant association between proteinuria and cardiovascular risk in renal transplant recipients, suggesting that this approach is grounded in established findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age of 18 - 75 years * Male and Female patients * Patients evaluated and accepted for living donor kidney transplantation with residual urine output of at least 500 ml/24 hours * Informed consent has to be given in written form Exclusion Criteria: * Patients in unstable conditions due to any kind of serious disease, that infers with the conduction of the trial * active Drug or alcohol abuse * Pregnant and breast-feeding patients * Body mass index \> 35 kg/m² * Subjects who do not give written consent, that pseudonymous data will be transferred in line with the duty of documentation and the duty of notification according to § 12 and § 13 GCP-V * Implanted pacemakers or defibrillators * Other implanted metallic devices, which are not MRI compatible * Claustrophobia * Any other relevant clinical contraindication of MRI examination
Where this trial is running
Erlangen
- Clinical Research Center, Department of Nephrology and Hypertension, University of Erlangen-Nuremberg — Erlangen, Germany (Recruiting)
Study contacts
- Study coordinator: Dennis Kannenkeril, MD
- Email: dennis.kannenkeril@uk-erlangen.de
- Phone: +49 9131 85
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.