Understanding oxygen use and organ injury after heart surgery
Oxygen Consumption, Early Postoperative Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass: a Prospective Observational Study
This study is trying to see how oxygen use after heart surgery affects organ health in adults to improve care after the operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 65 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Uppsala University Hospital Academic / other |
| Locations | 1 site (Uppsala, Sweden) |
| Trial ID | NCT06930443 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between oxygen consumption, blood flow issues, and organ injury in patients undergoing cardiac surgery with cardiopulmonary bypass. It focuses on individuals over 18 years old and will measure oxygen consumption using indirect calorimetry in the early hours post-surgery. Researchers will also monitor lactate levels and assess signs of organ injury in the heart, kidneys, liver, brain, and gut. The study will include 65 participants and aims to provide insights into postoperative care.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old scheduled for elective cardiac surgery requiring cardiopulmonary bypass.
Not a fit: Patients with severe anemia, high lactate levels before surgery, or those requiring intensive care may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve postoperative care and outcomes for patients undergoing cardiac surgery.
How similar studies have performed: While similar studies have explored oxygen consumption and organ injury, this specific observational approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elective cardiac surgery requiring cardiopulmonary bypass Exclusion Criteria: * Combined, redo or annuloplasty procedures * Surgical procedures involving other vascular cannulation than standard direct, such as bicaval or femoral cannulation * Preoperative hyperlactatemia (\>2mmol/L) or anaemia (Hb \<90 g/dL) * Preoperative need for supplementary oxygen or ICU care * Consent not obtainable.
Where this trial is running
Uppsala, Sweden
- Uppsala University Hospital — Uppsala, Sweden, Sweden (Recruiting)
Study contacts
- Study coordinator: Julia Jakobsson MD PhD
- Email: julia.o.jakobsson@akademiska.se
- Phone: +46-18-610 00 00
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.