Understanding oxygen use and organ injury after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between oxygen consumption, blood flow issues, and organ injury in patients undergoing cardiac surgery with cardiopulmonary bypass. It focuses on individuals over 18 years old and will measure oxygen consumption using indirect calorimetry in the early hours post-surgery. Researchers will also monitor lactate levels and assess signs of organ injury in the heart, kidneys, liver, brain, and gut. The study will include 65 participants and aims to provide insights into postoperative care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Elective cardiac surgery requiring cardiopulmonary bypass

Exclusion Criteria:

* Combined, redo or annuloplasty procedures
* Surgical procedures involving other vascular cannulation than standard direct, such as bicaval or femoral cannulation
* Preoperative hyperlactatemia (\>2mmol/L) or anaemia (Hb \<90 g/dL)
* Preoperative need for supplementary oxygen or ICU care
* Consent not obtainable.

Where it's running

• Uppsala University Hospital
  Uppsala, Sweden, Sweden Recruiting

Study contacts

• Study coordinator: Julia Jakobsson MD PhD
• Email: julia.o.jakobsson@akademiska.se
• Phone: +46-18-610 00 00

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.