Understanding outcomes of gender-affirming surgeries for trans-masculine and non-binary individuals

Patient Reported Outcomes After Gynaecological Gender Surgeries

Observational Amsterdam UMC, location VUmc · NCT06098781

This study looks at how gender-affirming surgeries like hysterectomy affect the quality of life and mental health of trans-masculine and non-binary individuals over time.

Quick facts

Study typeObservational
Enrollment57 (estimated)
Ages18 Years and up
SexAll
SponsorAmsterdam UMC, location VUmc Academic / other
Locations1 site (Amsterdam)
Trial IDNCT06098781 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess patient-reported outcomes following gynaecological gender-affirming surgeries, such as hysterectomy and tubectomy, in individuals assigned female at birth. Participants will complete questionnaires before surgery and at 3, 9, and 18 months post-operation to evaluate their experiences and effects of the surgeries. The study focuses on gathering data to better understand the impact of these procedures on the quality of life and mental health of trans-masculine and non-binary individuals.

Who should consider this trial

Good fit: Ideal candidates for this study are trans-masculine and non-binary individuals assigned female at birth who are scheduled to undergo gynaecological gender-affirming surgery.

Not a fit: Patients who are under 18 years old or those undergoing surgery combined with other procedures may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the benefits and challenges of gender-affirming surgeries, ultimately improving patient care and support.

How similar studies have performed: While there have been studies on gender-affirming surgeries, this specific focus on patient-reported outcomes in a prospective cohort is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* assigned female at birth
* scheduled to undergo gynaecological gender-affirming surgery (i.e. hysterectomy, ovariectomy, tubectomy and/or colpectomy)

Exclusion Criteria:

* age below 18 y/o
* surgery combined with other surgeries (e.g. urethroplasty, metoidioplasty)

Where this trial is running

Amsterdam

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Gender Dysphoriahysterectomycolpectomyvaginectomytubectomypatient-reported outcome measure
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.