Understanding metabolic responses after bariatric surgery
Genetic and Biochemical Characteristics of Medically-Complicated Obesity and Response to Bariatric Surgery
This study is looking to see how the body reacts after weight loss surgery in people with severe obesity by checking their genetic and tissue markers before and after the surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Trial ID | NCT02024542 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the genetic and biomechanical markers of adipose tissue in patients with morbid obesity undergoing Roux-en-Y gastric bypass surgery. Participants will be invited after completing a thorough pre-surgical evaluation at UC Davis Health System, including lab studies and educational programs. Blood, urine, and fecal samples will be collected pre-operatively, along with tissue samples during surgery. Post-operative observations will track weight loss and the resolution of co-morbidities, with additional lab studies conducted at designated times.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-55 who meet NIH criteria for bariatric surgery and have controlled dyslipidemia along with impaired glucose metabolism or type 2 diabetes.
Not a fit: Patients with uncontrolled metabolic syndrome, including uncontrolled diabetes, hypertension, or dyslipidemia, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of metabolic changes after bariatric surgery, potentially leading to improved treatment strategies for obesity and related conditions.
How similar studies have performed: Other studies have shown success in understanding metabolic responses to bariatric surgery, making this approach both relevant and promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Meet NIH Criteria for Bariatric Surgery * Between the Age of 18-55 * Dyslipidemia controlled with medication * Impaired glucose metabolism or type 2 diabetes Exclusion Criteria: * Uncontrolled Metabolic syndrome (uncontrolled diabetes, htn, dyslipidemia), one or all conditions.
Where this trial is running
Sacramento, California
- University of California Davis Medical Center — Sacramento, California, United States (Recruiting)
Study contacts
- Principal investigator: Mohamed R Ali, MD — University of California Davis Health System
- Study coordinator: Mohamed R Ali, MD
- Email: mrali@ucdavis.edu
- Phone: 916-734-7290
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.