Clinical trial Recruiting at 1 site Observational Ages 18 to 55

Understanding metabolic responses after bariatric surgery

Official title: Genetic and Biochemical Characteristics of Medically-Complicated Obesity and Response to Bariatric Surgery

Run by University of California, Davis · NCT02024542 · Data updated 2026-11-12

This study is looking to see how the body reacts after weight loss surgery in people with severe obesity by checking their genetic and tissue markers before and after the surgery.

Quick facts

Study typeObservational
Ages18 Years to 55 Years
SexAll
Enrollment500 (estimated)
SponsorUniversity of California, Davis
Academic / other
Locations1 site (Sacramento, California)
StatusRecruiting
StartedFebruary 2011
Main results expectedApril 2035
Study endsApril 2035
Registry record updatedMay 18, 2026
Trial IDNCT02024542 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18-55 who meet NIH criteria for bariatric surgery and have controlled dyslipidemia along with impaired glucose metabolism or type 2 diabetes.

Probably not a fit

Patients with uncontrolled metabolic syndrome, including uncontrolled diabetes, hypertension, or dyslipidemia, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the genetic and biomechanical markers of adipose tissue in patients with morbid obesity undergoing Roux-en-Y gastric bypass surgery. Participants will be invited after completing a thorough pre-surgical evaluation at UC Davis Health System, including lab studies and educational programs. Blood, urine, and fecal samples will be collected pre-operatively, along with tissue samples during surgery. Post-operative observations will track weight loss and the resolution of co-morbidities, with additional lab studies conducted at designated times.

Why it matters

Potential benefit: If successful, this study could enhance understanding of metabolic changes after bariatric surgery, potentially leading to improved treatment strategies for obesity and related conditions.

How similar studies have gone: Other studies have shown success in understanding metabolic responses to bariatric surgery, making this approach both relevant and promising.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Meet NIH Criteria for Bariatric Surgery
* Between the Age of 18-55
* Dyslipidemia controlled with medication
* Impaired glucose metabolism or type 2 diabetes

Exclusion Criteria:

* Uncontrolled Metabolic syndrome (uncontrolled diabetes, htn, dyslipidemia), one or all conditions.

Where it's running

  • University of California Davis Medical Center
    Sacramento, California, United States
    Recruiting

Study contacts

  • Principal investigator: Mohamed R Ali, MD — University of California Davis Health System
  • Study coordinator: Mohamed R Ali, MD
  • Email: mrali@ucdavis.edu
  • Phone: 916-734-7290

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.