Understanding metabolic responses after bariatric surgery
Official title: Genetic and Biochemical Characteristics of Medically-Complicated Obesity and Response to Bariatric Surgery
Run by University of California, Davis · NCT02024542 · Data updated 2026-11-12
This study is looking to see how the body reacts after weight loss surgery in people with severe obesity by checking their genetic and tissue markers before and after the surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Status | Recruiting |
| Started | February 2011 |
| Main results expected | April 2035 |
| Study ends | April 2035 |
| Registry record updated | May 18, 2026 |
| Trial ID | NCT02024542 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-55 who meet NIH criteria for bariatric surgery and have controlled dyslipidemia along with impaired glucose metabolism or type 2 diabetes.
✕Probably not a fit
Patients with uncontrolled metabolic syndrome, including uncontrolled diabetes, hypertension, or dyslipidemia, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the genetic and biomechanical markers of adipose tissue in patients with morbid obesity undergoing Roux-en-Y gastric bypass surgery. Participants will be invited after completing a thorough pre-surgical evaluation at UC Davis Health System, including lab studies and educational programs. Blood, urine, and fecal samples will be collected pre-operatively, along with tissue samples during surgery. Post-operative observations will track weight loss and the resolution of co-morbidities, with additional lab studies conducted at designated times.
Why it matters
Potential benefit: If successful, this study could enhance understanding of metabolic changes after bariatric surgery, potentially leading to improved treatment strategies for obesity and related conditions.
How similar studies have gone: Other studies have shown success in understanding metabolic responses to bariatric surgery, making this approach both relevant and promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Meet NIH Criteria for Bariatric Surgery * Between the Age of 18-55 * Dyslipidemia controlled with medication * Impaired glucose metabolism or type 2 diabetes Exclusion Criteria: * Uncontrolled Metabolic syndrome (uncontrolled diabetes, htn, dyslipidemia), one or all conditions.
Where it's running
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University of California Davis Medical Center
Sacramento, California, United States Recruiting
Study contacts
- Principal investigator: Mohamed R Ali, MD — University of California Davis Health System
- Study coordinator: Mohamed R Ali, MD
- Email: mrali@ucdavis.edu
- Phone: 916-734-7290
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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TSBL-based vs BMI-based limb length in one-anastomosis gastric bypass
This trial tests whether calculating the biliopancreatic limb length by total small bowel length (TSBL) helps weight loss and safety more than using standard BMI-based lengths in adults undergoing a single-center OAGB for obesity.
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Gut stool tests after sleeve vs gastric bypass
This study tests whether routine stool tests can reveal changes in gut function six months after sleeve gastrectomy or gastric bypass in adults with morbid obesity.
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Impact of Bariatric Surgery on Female Sexual Function and Hormones
This observational study will see how weight loss surgery affects sexual function and hormone levels in women with severe obesity, six months after surgery.
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Dual-chamber patient-controlled pain relief after laparoscopic sleeve gastrectomy
This test checks whether a dual-chamber IV patient-controlled pump delivering fentanyl plus ketorolac reduces pain and postoperative nausea and vomiting in adults having laparoscopic sleeve gastrectomy.
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Exercise program to improve weight, strength, and recovery around bariatric surgery
This program will test whether a structured exercise plan supported by telerehabilitation helps adults with severe obesity who are having bariatric surgery lose more body fat and gain more strength than usual care.
-
Comparing rivaroxaban and enoxaparin for preventing blood clots in obese patients undergoing weight loss surgery
This study tests whether the blood thinner rivaroxaban works better than enoxaparin to prevent blood clots in obese patients having weight loss surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.