Understanding lymphatic dysfunction in lymphedema

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the molecular and histological differences between primary and secondary lymphedema, conditions characterized by impaired lymphatic function and swelling. It aims to analyze gene expression in patients who have developed lymphedema, either inherited or as a result of cancer treatment. By utilizing micro-biopsies, the study seeks to uncover potential therapeutic strategies to restore lymphatic function. The research is conducted at the University Hospital in Toulouse, focusing on patients with specific eligibility criteria related to their lymphedema condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients in who developed primary lymphedema or secondary lymphedema after breast cancer treatment.
2. Male and female over the age of 18 and under 75.
3. Patient affiliated to a social security scheme in France.
4. Patient having signed informed consent prior to inclusion in the study and prior to any specific procedure for the study.
5. Patients with no recidive \> 3 years after cancer surgery.
6. Patients with Body Mass Index \<35.
7. Patient enrolled in a care pathway for the management of their lymphedema (medical and educational care).
8. Patients wearing a compression orthosis on the limb with lymphedema.

Exclusion Criteria:

1. Patients with strong suspicion or with active bacterial or fungal infection.
2. Patient with venous insufficiency associated with lymphedema.
3. Patient with a history of deep venous thrombosis on the limb with lymphedema.
4. History of chronic inflammatory disease.
5. Active neoplasia during parallel management.
6. Patient already included in another therapeutic trial.
7. Pregnant or breastfeeding woman.
8. Metastatic cancer.
9. Bilateral breast cancer.
10. Obliterative arterial disease.
11. Multiple erysipelas.
12. Active smoking (delayed healing).
13. Medicines that may promote delayed healing (Corticosteroid therapy, immunosuppressants).
14. Medication that thins the blood (aspirin and antiplatelet agent, anti-coagulant).
15. Betadine allergy.
16. Patient under guardianship or trusteeship, persons placed under the protection of justice

Where it's running

• Toulouse Hospital
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Julie Malloizel-Delaunay, MD — University Hospital, Toulouse
• Study coordinator: Julie MALLOIZEL-DELAUNAY, MD
• Email: malloizel-delaunay.j@chu-toulouse.fr
• Phone: +33 (0)5 61 32 30 33

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Use of reconstructive microsurgery to treat lymphedema

  This study tests whether reconstructive microsurgery, with or without the help of indocyanine green imaging, can help people with lymphedema feel and function better by improving lymphatic drainage.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT07889856

• Predicting lymphedema risk in inflammatory breast cancer patients using preoperative body impedance analysis

  This study tests whether a preoperative bioimpedance test can help identify IBC patients who are at risk for developing lymphedema.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07855627

• Boosted compression for lower limb edema

  This study tests whether applying a multicomponent short-stretch bandage three times daily (boosted compression) helps reduce edema faster in people with chronic edema or lymphedema of the legs, compared with the standard single daily bandage.

  Recruiting at 4 sites Universiteit Antwerpen · Edegem, Antwerp and 3 other locations · NCT07708662

• Erector Spinae Block vs Paravertebral Block for Chronic Pain After Mastectomy

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  Recruiting American University of Beirut Medical Center · Beirut · NCT07561411

• Resistance exercise for people with lower-limb lymphedema

  This study tests whether short periods of supervised resistance exercise, with and without compression garments, change swelling or symptoms in people with lower-limb lymphedema.

  Recruiting Herlev and Gentofte Hospital · Herlev · NCT07558317

• Tracking body composition changes after breast cancer treatment

  This project will see how muscle mass and fat distribution change over two years in adults treated for stage I–III breast cancer.

  Recruiting Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation · New Taipei City, Xindian Dist · NCT07472803

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.