Understanding left ventricular thrombus after heart attacks
Exploration of Cardiovascular Thrombus Activity Post Myocardial Infarction by Using 18F-GP1 MR/PET
University of Edinburgh · NCT04829825
This study looks at how often blood clots form in the heart after a heart attack and checks if these clots can lead to strokes in patients using advanced imaging techniques.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | University of Edinburgh (other) |
| Locations | 1 site (Edinburgh) |
| Trial ID | NCT04829825 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the incidence and natural history of left ventricular thrombus in patients who have recently experienced an acute anterior myocardial infarction. By utilizing advanced hybrid positron emission tomography and magnetic resonance imaging (PET/MR), the study will screen participants for evidence of thrombus and subclinical stroke. Patients will undergo imaging 7±2 days post-myocardial infarction to assess the presence of thrombus and explore the expression of GP IIb/IIIa receptors, which are crucial in the thrombotic process.
Who should consider this trial
Good fit: Ideal candidates are males and females over 40 years old who have had a recent acute type 1 anterior myocardial infarction.
Not a fit: Patients who are unable to provide informed consent or those with severe comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of thrombus formation and lead to improved treatment strategies for patients with cardiovascular complications.
How similar studies have performed: While there have been studies on thrombus in myocardial infarction, this specific approach using PET/MR imaging for detailed assessment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or females over the age of 40 with recent (within 21±2 days) acute type 1 anterior myocardial infarction * Provision of informed consent prior to any study specific procedures Exclusion Criteria: * Inability or unwilling to give informed consent. * Concomitant use of anticoagulation agents (warfarin, apixaban, edoxaban, rivaroxaban, dabigatran or SC/IV Heparin) (Cohort 1 only) * Unable to tolerate the supine position * Impaired renal function with eGFR of \<30 mL/min/1.73m2 * Severe or significant comorbidity * Women who are pregnant or breastfeeding • Severe claustrophobia
Where this trial is running
Edinburgh
- Royal Infirmary Edinburgh — Edinburgh, United Kingdom (RECRUITING)
Study contacts
- Study coordinator: Evangelos Tzolos, MD
- Email: Evan.tzolos@gmail.com
- Phone: 07412959799
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Left Ventricular Thrombus, Thrombosis, STEMI, Stroke