Understanding late fetal organ development
Official title: Study of Late-foetal Human Organ Development
Run by University College London Hospitals · NCT04661059 · Data updated 2026-11-12
This study looks at how fetal organs develop in the later stages of pregnancy to help us understand birth defects and improve treatments for them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | University College London Hospitals Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | February 3, 2022 |
| Main results expected | September 30, 2024 |
| Study ends | December 31, 2040 |
| Registry record updated | December 5, 2023 |
| Trial ID | NCT04661059 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant women aged 18 and older who have concerns about fetal abnormalities and decide to proceed with termination of pregnancy.
✕Probably not a fit
Patients who are unable to make an informed decision about termination of pregnancy or have positive screening labs for certain infections will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to gather knowledge about normal and abnormal organ development during the last two-thirds of pregnancy, a critical period for fetal tissue remodeling. It involves collecting tissue samples from various developing fetal organs from women who choose to undergo termination of pregnancy and consent to a clinical fetal postmortem examination. The findings could enhance our understanding of congenital disorders and inform future treatment approaches for affected individuals.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for congenital disorders.
How similar studies have gone: While there is limited research on late fetal organ development, studies focusing on early fetal tissues have shown promise, making this approach novel and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥18 years old pregnant women who attend the Fetal Medicine Unit for concerns about a fetal abnormality where they decide to proceed to termination of pregnancy Exclusion Criteria: * Screening labs positive for maternal HIV, Hepatitis B and Hepatitis C, Chlamydia and Herpes. * Subject unable to make an informed decision about termination of pregnancy.
Where it's running
-
University College Hospitals NHS Foundation Trust
London, United Kingdom Recruiting
Study contacts
- Study coordinator: Sarah Gibbon
- Email: sarah.gibbon1@nhs.net
- Phone: +44 20 3456 7890
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.