Understanding late fetal organ development
Study of Late-foetal Human Organ Development
This study looks at how fetal organs develop in the later stages of pregnancy to help us understand birth defects and improve treatments for them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University College London Hospitals Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT04661059 on ClinicalTrials.gov |
What this trial studies
This observational study aims to gather knowledge about normal and abnormal organ development during the last two-thirds of pregnancy, a critical period for fetal tissue remodeling. It involves collecting tissue samples from various developing fetal organs from women who choose to undergo termination of pregnancy and consent to a clinical fetal postmortem examination. The findings could enhance our understanding of congenital disorders and inform future treatment approaches for affected individuals.
Who should consider this trial
Good fit: Ideal candidates are pregnant women aged 18 and older who have concerns about fetal abnormalities and decide to proceed with termination of pregnancy.
Not a fit: Patients who are unable to make an informed decision about termination of pregnancy or have positive screening labs for certain infections will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for congenital disorders.
How similar studies have performed: While there is limited research on late fetal organ development, studies focusing on early fetal tissues have shown promise, making this approach novel and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥18 years old pregnant women who attend the Fetal Medicine Unit for concerns about a fetal abnormality where they decide to proceed to termination of pregnancy Exclusion Criteria: * Screening labs positive for maternal HIV, Hepatitis B and Hepatitis C, Chlamydia and Herpes. * Subject unable to make an informed decision about termination of pregnancy.
Where this trial is running
London
- University College Hospitals NHS Foundation Trust — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Sarah Gibbon
- Email: sarah.gibbon1@nhs.net
- Phone: +44 20 3456 7890
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.