Clinical trial Recruiting at 1 site Observational Ages 18 and up

Observing lung cancer in never-smokers in the UK

Official title: An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

Run by University College London Hospitals · NCT06575439 · Data updated 2026-11-12

This study looks at lung cancer in people who have never smoked to see how we can find it earlier and understand what might cause it.

More Lung Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment225 (estimated)
SponsorUniversity College London Hospitals
Academic / other
Locations1 site (London)
StatusRecruiting
StartedSeptember 17, 2024
Main results expectedSeptember 2029
Study endsSeptember 2029
Registry record updatedDecember 12, 2024
Trial IDNCT06575439 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who have been diagnosed or treated for primary lung cancer and have never smoked more than 100 cigarettes.

Probably not a fit

Patients who have ever smoked more than 100 cigarettes or have used nicotine replacement therapy will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance early detection of lung cancer in adults who have never smoked more than 100 cigarettes. It will analyze participant demographics, co-morbidities, environmental exposures, and their pathways to diagnosis, including symptoms and treatment outcomes. The study will also assess various factors, both modifiable and non-modifiable, that may influence lung cancer in this population, utilizing environmental measures, blood tests, and genomic data. Participants will continue with their usual care throughout the study.

Why it matters

Potential benefit: If successful, this study could lead to improved early detection and treatment strategies for lung cancer in never-smokers.

How similar studies have gone: While there have been studies on lung cancer in smokers, this specific focus on never-smokers is relatively novel and less explored.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site

Exclusion Criteria:

* Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as:

  * More than 100 cigarettes or 75g tobacco in their lifetime
  * Those who have received a prescription for nicotine replacement therapy
* For prospective participants, those who cannot consent will be excluded

Where it's running

  • University College London Hospital
    London, United Kingdom
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.