Understanding KCNQ2 Gene-related Neonatal Seizures
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy
This study looks at the causes of seizures in newborns linked to the KCNQ2 gene to help improve how these infants are identified and treated.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 0 Days to 28 Days |
| Sex | All |
| Sponsor | Children's Hospital of Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT03934268 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the causes and influencing factors of neonatal seizures associated with the KCNQ2 gene. Researchers will assess the prognosis of infants experiencing these seizures, focusing on improving identification, intervention, and management strategies. The study will involve infants under 28 days old who have experienced their first seizure, with a particular emphasis on genetic factors contributing to their condition. By gathering data on these cases, the study seeks to enhance health education and preventive measures for affected families.
Who should consider this trial
Good fit: Ideal candidates for this study are newborns under 28 days old who have experienced their first seizure.
Not a fit: Patients with seizures caused by congenital brain malformations or other systemic syndromes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management and outcomes for infants with KCNQ2-related seizures.
How similar studies have performed: While there is limited international reporting on KCNQ2-related neonatal seizures, the study builds on emerging insights into genetic factors influencing neonatal convulsions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Primary or initial convulsion * Postnatal age \<28 days. * Seizure in the neonatal period * Informed consent of parents Exclusion Criteria: * Seizure caused by congenital cerebral hypoplasia or multiple structural malformations. * Seizure caused by other system-related syndromes. * Seizure caused by perinatal or postpartum factors such as HIE, infection, intracranial hemorrhage, etc.
Where this trial is running
Shanghai, Shanghai
- Children Hospital of Fudan University — Shanghai, Shanghai, China (Recruiting)
Study contacts
- Study coordinator: Wenhao Zhou, Prof.
- Email: zwhchfu@126.com
- Phone: (+86) 021-64931168
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.