Understanding immune responses to influenza vaccination in health care workers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance knowledge about the immune responses elicited by influenza vaccination among health care personnel over a 10-year period. Participants will receive the seasonal influenza vaccine as per routine occupational health care practices, with blood samples collected before vaccination, five weeks after, and six months post-vaccination. The study will analyze both humoral and cellular immunity, the effects of repeated vaccinations, and factors influencing immunological responses. The analysis will primarily be descriptive, focusing on the duration of protection and immunity against circulating viruses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Members of health care or laboratory personnel in HUS having decided to take the seasonal influenza vaccination by the routine occupational health care service
* General good health as established by or volunteer's own statement
* Written informed consent
* Presumably able and willing to participate in the study during the starting influenza season

Exclusion Criteria:

* Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection.
* Administration (longer than 14 days) of immunosuppressants or other immune- modifying drugs within 6 months before the vaccination; oral corticosteroids in dosages of 20 mg/day or more prednisolone or equivalent are excluded; inhaled or topical steroids are allowed.
* Pregnancy or lactation
* Acute disease at the time of enrolment (defined as the presence of a moderate or severe illness with or without fever)
* Contraindication for influenza vaccination
* Any other criteria which, in the investigator's or dedicated study staff member's opinion, would compromise the ability of a subject to participate in the study, a subject's well-being, or the outcome of the study

Where it's running

• The Hospital District of Helsinki and Uusimaa
  Helsinki, Finland Recruiting

Study contacts

• Principal investigator: Hanna Nohynek, MD, PhD — Finnish Institute for Health and Welfare
• Study coordinator: Hanna Nohynek, MD, PhD
• Email: hanna.nohynek@thl.fi
• Phone: +358 29 524 8246

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.