Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Understanding immune deficiency in untreated Chronic Lymphocytic Leukemia patients

Official title: Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk

Run by CHU de Reims · NCT06475469 · Data updated 2026-11-12

This study looks at how untreated Chronic Lymphocytic Leukemia affects the immune system and tries to find out why these patients are more likely to get infections.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment75 (estimated)
SponsorCHU de Reims
Academic / other
Locations1 site (Reims)
StatusRecruiting
StartedMay 10, 2022
Main results expectedJune 2028
Study endsJune 2028
Registry record updatedJune 26, 2024
Trial IDNCT06475469 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are untreated patients over 18 years of age diagnosed with Chronic Lymphocytic Leukemia.

Probably not a fit

Patients who have previously received treatment for Chronic Lymphocytic Leukemia or are legally protected may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the immune dysfunction associated with untreated Chronic Lymphocytic Leukemia (CLL) and aims to identify predictive factors for infectious risk in these patients. It involves blood sampling and chest CT scans to assess lymphocyte subpopulations and the prevalence of bronchiectasis. The research focuses on understanding how CLL leads to immunosuppression and increased susceptibility to infections, which are significant complications in these patients. By analyzing these factors, the study seeks to improve patient management and outcomes.

Why it matters

Potential benefit: If successful, this study could lead to better risk assessment and management strategies for infections in patients with Chronic Lymphocytic Leukemia.

How similar studies have gone: While the specific approach of this study may be novel, there is existing literature on the immune dysfunction in CLL, suggesting that similar studies have provided valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Untreated CLL patients
* Patients \> 18 years of age
* Patients agreing to participate to the study
* Patients inured under the french social security system

Exclusion Criteria:

* Previously treated CLL patients
* Patients protected by law

Where it's running

  • Chu Reims
    Reims, France
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.