Understanding immune and inflammatory factors in acute coronary syndrome
Identificación de la relación Entre Componentes de la Inmunidad Celular y Factores Inflamatorios y neuroendócrinos Como Determinantes Del pronóstico clínico en el síndrome Coronario Agudo
This study looks at how stress hormones and inflammation in the body affect recovery in people with acute coronary syndrome to see if they can help predict health outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Hospital de Clinicas José de San Martín Academic / other |
| Locations | 1 site (Buenos Aires) |
| Trial ID | NCT06513611 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between cortisol levels, inflammatory markers, and cellular immunity in patients diagnosed with acute coronary syndrome (ACS). It will involve a prospective analysis of consecutive ACS patients admitted to the Coronary Unit, with follow-up conducted via telephone for up to six months post-discharge. The study seeks to establish how these biological factors can serve as prognostic indicators during hospitalization and after recovery. By examining these correlations, the research hopes to provide insights into the broader implications of stress and inflammation in ACS.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 21 years old who have been admitted with a diagnosis of acute coronary syndrome.
Not a fit: Patients with chronic neoplastic or inflammatory diseases, recent acute myocardial infarction, or those on chronic corticosteroid treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of prognostic factors in ACS, potentially leading to improved patient management and outcomes.
How similar studies have performed: While the specific approach of this study may be novel, previous studies have indicated the importance of inflammatory and stress responses in cardiovascular conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Are over 21 years of age and admitted to the Coronary Unit of the Hospital de Clínicas with a diagnosis of Acute Coronary Syndrome (ACS). * Agree to participate in the study through informed consent. Exclusion Criteria: * Concomitant diagnosis of chronic neoplastic or inflammatory disease. * Diagnosis of allergic disease, parasitic disease, asthma, or hypereosinophilic syndrome. * Severe associated valvular disease. * Acute myocardial infarction (AMI) in the previous month. * Chronic corticosteroid treatment. * Creatinine clearance \<30% by MDRD (Modification of Diet in Renal Disease). * Severe hepatic insufficiency. * Pregnant women. * Known disease that limits their life expectancy to 6 months. * Refuse to participate in the study either by their own will or unable to understand its characteristics due to their clinical condition.
Where this trial is running
Buenos Aires
- Hospital de Clinicas Jose de San Martin — Buenos Aires, Argentina (Recruiting)
Study contacts
- Study coordinator: Diego Costa, MD, MSc.
- Email: diegosta@gmail.com
- Phone: 54 9 11 6198 4472
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.