Understanding how white blood cells affect lung inflammation in patients on ventilators

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational clinical trial aims to investigate the role of macrophages, a type of white blood cell, in lung inflammation among patients with Acute Respiratory Distress Syndrome (ARDS). The study will compare macrophages from ARDS patients to those from individuals with healthy lungs to understand how the immune system responds to different lung injuries. Additionally, it will explore whether more frequent testing of lung cell samples can expedite treatment for ventilator-associated pneumonia (VAP). Participants will be adults on mechanical ventilation in the ICU, either due to ARDS or other conditions. The study involves collecting lung fluid samples and nasal brushes for analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent (by LAR if subject unconscious or has altered mental status) prior to any study procedures. Verbal consent may be used as necessary
* Adults greater than 18 years of age
* Admission to the intensive care unit.
* Orally/nasally intubated or expected to be intubated within 48 hours

Exclusion Criteria:

* History of solid organ or bone marrow transplantation
* Severe or massive hemoptysis
* At significant risk for bleeding (INR \> 3 or PTT \> 3x normal)
* Presence of pneumomediastinum or pneumothorax on recent imaging
* Presence of an advanced directive with Do Not Intubate (DNI) status (Do Not Resuscitate (DNR) is acceptable)
* Morbid state or expected to survive less than 24 hours because of an advanced co-morbid medical condition in the opinion of the PI and/or clinical team and attending physician.
* Pregnancy

Where it's running

• Intermountain Health - St. Joseph's Hospital - National Jewish Health
  Denver, Colorado, United States Recruiting

Study contacts

• Study coordinator: Olivia VerBurg
• Email: verburgo@njhealth.org
• Phone: 303-398-1201

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Corticosteroids for a hyperinflammatory state in critical illness

  This trial tests whether methylprednisolone helps improve organ function and survival in adults with sepsis or ARDS who show a hyperinflammatory profile.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07511582

• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

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• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

  This trial tests whether IV umbilical‑cord mesenchymal stem cells, alone or with secretome, help adults with severe ARDS recover lung function and reduce inflammation.

  Recruiting Phase 1/2 PT. Prodia Stem Cell Indonesia · Jakarta Pusat, DKI Jakarta · NCT07439848

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.