Understanding how the eye adjusts focus and its changes with age
Official title: To Study the Changes Under Different Accommodation of Anterior Eye in People of Different Ages and 3D Crystal Reconstruction.
Run by Second Affiliated Hospital, Zhejiang University, School of Medicine · NCT06704503 · Data updated 2026-11-12
This study is trying to understand how our eyes change focus as we age and what causes the difficulty in seeing things up close, known as presbyopia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Second Affiliated Hospital, Zhejiang University, School of Medicine Academic / other |
| Locations | 2 sites (Hangzhou, Zhejiang and 1 other locations) |
| Status | Recruiting |
| Started | November 27, 2024 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | May 23, 2025 |
| Trial ID | NCT06704503 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with astigmatism of -1.50D or less and a best corrected visual acuity of 4.9 or better.
✕Probably not a fit
Patients with systemic diseases, a history of eye surgery, or other specific eye conditions such as strabismus or amblyopia may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the process of accommodation in the human eye, which is the ability to change focus for near and far objects. It aims to clarify the controversial nature of accommodation and the age-related changes that lead to presbyopia. Utilizing advanced imaging techniques like Anterior Segment Optical Coherence Tomography (AS-OCT), the study will capture the morphology of the anterior segment structures and their responses to different stimuli. The research seeks to provide insights into the mechanisms behind accommodation and presbyopia, which remain poorly understood despite extensive investigation.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of eye accommodation and lead to better treatments for presbyopia.
How similar studies have gone: While the study addresses a well-researched topic, the use of advanced imaging techniques like AS-OCT may provide novel insights that have not been extensively explored in previous studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: · Patients with astigmatism ≤-1.50D and best corrected visual acuity ≥4.9 Exclusion Criteria: * Patients with other systemic diseases * Patients with a history of eye surgery * Patients with intraocular lens or aphakia * Patients with strabismus and amblyopia * Pregnant or lactating women * People with mental disorders or neurological diseases who cannot cooperate with the examination
Where it's running
-
Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China Recruiting -
Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China Not yet recruiting
Study contacts
- Principal investigator: Wen Xu, Phd — Second Affiliated Hospital, Zhejiang University, School of Medicine
- Study coordinator: Wen Xu, Phd
- Email: xuwen2003@zju.edu.cn
- Phone: +86-13858185223
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.