Predicting cycloplegic refractive error in myopia using standard eye measurements

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study develops and validates a machine learning model that estimates cycloplegic refractive error from non-cycloplegic measurements in adult myopes. Data are drawn from preoperative evaluations at a refractive surgery center, where paired non-cycloplegic and cycloplegic refractions with detailed anterior segment biometry are available. The goal is to identify which patients can avoid cycloplegia while still receiving accurate prescriptions. The project addresses variability in cycloplegic-versus non-cycloplegic refraction among individuals and aims to enable safer, faster clinical decisions. The study leverages non-linear modeling approaches to improve prediction accuracy in adults, a relatively underexplored area compared with pediatric populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18 to 60 years, of either sex;
2. Spherical equivalent between -0.50 diopters and -10.00 diopters, with myopia in one or both eyes, and with cylinder of 4.00 diopters or less;
3. Best-corrected visual acuity of 20/25 or better in each eye;
4. Clear cornea, no keratoconus, corneal scarring, or other pathologies; clear lens;
5. Intraocular pressure of 21 mmHg or less, with no history of glaucoma;
6. No history of ocular surgery, especially corneal refractive surgery or cataract surgery;
7. Time interval between non-cycloplegic refraction and cycloplegic refraction of 7 days or less, with complete data.

Exclusion Criteria:

1. Incomplete clinical data to support the diagnosis;
2. Ocular conditions such as subclinical keratoconus, keratoconus, or moderate-to-severe corneal haze or leukoma;
3. Allergy or contraindication to cycloplegic agents;
4. Refusal to participate in the study.

Where it's running

• The Second Affiliated Hospital of Nanchang University, Nanchang, JiangXi 330000
  Jiangxi, China Recruiting

Study contacts

• Study coordinator: jian xiong
• Email: 894040417@qq.com
• Phone: 18170906556

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.