Understanding how the brain navigates in real-world environments
Official title: Neural Correlates of Real World Spatial Navigation in Humans
Run by Duke University · NCT04874220 · Data updated 2026-11-12
This study is testing how brain stimulation can improve navigation and memory in people while they complete tasks in virtual and real-world environments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Duke University Academic / other |
| Locations | 2 sites (Los Angeles, California and 1 other locations) |
| Status | Recruiting |
| Started | September 30, 2020 |
| Main results expected | June 30, 2027 |
| Study ends | June 30, 2027 |
| Registry record updated | September 28, 2026 |
| Trial ID | NCT04874220 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 12 years or older who have undergone RNS system placement and can provide informed consent.
✕Probably not a fit
Patients who are unwilling to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the neural mechanisms involved in spatial navigation by utilizing deep brain recordings and stimulation during various memory tasks in virtual reality, augmented reality, and real-world settings. Participants will engage in tasks that assess cognitive and behavioral factors influencing deep brain activity. The research will focus on how memory-enhancing deep brain stimulation can affect navigation performance and memory recall.
Why it matters
Potential benefit: If successful, this study could lead to improved treatments for memory-related conditions by enhancing spatial navigation abilities.
How similar studies have gone: While the approach of using deep brain stimulation in navigation tasks is innovative, similar studies have shown promise in understanding brain functions related to memory and navigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older and has undergone RNS system placement * Willing to provide informed consent and participate the study * Ability to read and write English fluently Exclusion Criteria: * Unwilling to provide informed consent
Where it's running
-
University of California, Los Angeles
Los Angeles, California, United States Recruiting -
Duke University
Durham, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Nanthia Suthana, PhD — University of California, Los Angeles
- Study coordinator: Aaron Halvorsen, PhD
- Email: suthanalab@duke.edu
- Phone: 9196812577
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.