Clinical trial Recruiting at 2 sites Interventional Ages 18 to 90

Understanding how the brain navigates in real-world environments

Official title: Neural Correlates of Real World Spatial Navigation in Humans

Run by Duke University · NCT04874220 · Data updated 2026-11-12

This study is testing how brain stimulation can improve navigation and memory in people while they complete tasks in virtual and real-world environments.

Quick facts

Study typeInterventional
Ages18 Years to 90 Years
SexAll
Enrollment70 (estimated)
SponsorDuke University
Academic / other
Locations2 sites (Los Angeles, California and 1 other locations)
StatusRecruiting
StartedSeptember 30, 2020
Main results expectedJune 30, 2027
Study endsJune 30, 2027
Registry record updatedSeptember 28, 2026
Trial IDNCT04874220 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals aged 12 years or older who have undergone RNS system placement and can provide informed consent.

Probably not a fit

Patients who are unwilling to provide informed consent will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the neural mechanisms involved in spatial navigation by utilizing deep brain recordings and stimulation during various memory tasks in virtual reality, augmented reality, and real-world settings. Participants will engage in tasks that assess cognitive and behavioral factors influencing deep brain activity. The research will focus on how memory-enhancing deep brain stimulation can affect navigation performance and memory recall.

Why it matters

Potential benefit: If successful, this study could lead to improved treatments for memory-related conditions by enhancing spatial navigation abilities.

How similar studies have gone: While the approach of using deep brain stimulation in navigation tasks is innovative, similar studies have shown promise in understanding brain functions related to memory and navigation.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years of age or older and has undergone RNS system placement
* Willing to provide informed consent and participate the study
* Ability to read and write English fluently

Exclusion Criteria:

* Unwilling to provide informed consent

Where it's running

  • University of California, Los Angeles
    Los Angeles, California, United States
    Recruiting
  • Duke University
    Durham, North Carolina, United States
    Recruiting

Study contacts

  • Principal investigator: Nanthia Suthana, PhD — University of California, Los Angeles
  • Study coordinator: Aaron Halvorsen, PhD
  • Email: suthanalab@duke.edu
  • Phone: 9196812577

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.