Measuring free cloxacillin levels during continuous infusion
Concentration of Unbound Cloxacillin in Adults Treated With Continuous Infusion Via Elastomeric Pump
This tests whether continuous cloxacillin infusions produce the right unbound antibiotic levels in adults treated for Staphylococcal infections.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Region Västmanland Academic / other |
| Locations | 1 site (Västerås) |
| Trial ID | NCT06848387 on ClinicalTrials.gov |
What this trial studies
The trial measures unbound (free) concentrations of cloxacillin in adults receiving continuous infusion to determine whether levels remain within a therapeutic range. Blood samples will be taken during infusion and analyzed for free drug concentration. Collected data on age, sex, kidney function, and serum protein will be used to construct a PK/PD model to predict individualized dosing. The model aims to guide dosing that balances treatment effectiveness with safety.
Who should consider this trial
Good fit: Adults (18+) who have been started on continuous cloxacillin infusion by their treating physician and can give written informed consent.
Not a fit: People not receiving continuous cloxacillin infusion or who cannot or will not provide written consent would not be eligible and are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the results could allow doctors to tailor cloxacillin dosing to individual patients so infections are treated effectively while reducing side effects.
How similar studies have performed: PK/PD modeling and continuous infusion approaches with other beta‑lactam antibiotics have informed dosing strategies, but unbound cloxacillin during continuous infusion has been less thoroughly characterized.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Treating physician has decided to start continuous infusion of cloxacillin Exclusion Criteria: * Unwilling or unable to provide written informed consent
Where this trial is running
Västerås
- Västmanlands sjukhus Västerås — Västerås, Sweden (Recruiting)
Study contacts
- Study coordinator: Emeli Månsson, PhD
- Email: emeli.mansson@regionvastmanland.se
- Phone: 004621173000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.