Measuring free cloxacillin levels during continuous infusion
Official title: Concentration of Unbound Cloxacillin in Adults Treated With Continuous Infusion Via Elastomeric Pump
Run by Region Västmanland · NCT06848387 · Data updated 2026-11-12
This tests whether continuous cloxacillin infusions produce the right unbound antibiotic levels in adults treated for Staphylococcal infections.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | Region Västmanland Academic / other |
| Locations | 1 site (Västerås) |
| Status | Recruiting |
| Started | January 14, 2026 |
| Main results expected | December 2026 |
| Study ends | December 2027 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT06848387 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who have been started on continuous cloxacillin infusion by their treating physician and can give written informed consent.
✕Probably not a fit
People not receiving continuous cloxacillin infusion or who cannot or will not provide written consent would not be eligible and are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial measures unbound (free) concentrations of cloxacillin in adults receiving continuous infusion to determine whether levels remain within a therapeutic range. Blood samples will be taken during infusion and analyzed for free drug concentration. Collected data on age, sex, kidney function, and serum protein will be used to construct a PK/PD model to predict individualized dosing. The model aims to guide dosing that balances treatment effectiveness with safety.
Why it matters
Potential benefit: If successful, the results could allow doctors to tailor cloxacillin dosing to individual patients so infections are treated effectively while reducing side effects.
How similar studies have gone: PK/PD modeling and continuous infusion approaches with other beta‑lactam antibiotics have informed dosing strategies, but unbound cloxacillin during continuous infusion has been less thoroughly characterized.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Treating physician has decided to start continuous infusion of cloxacillin Exclusion Criteria: * Unwilling or unable to provide written informed consent
Where it's running
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Västmanlands sjukhus Västerås
Västerås, Sweden Recruiting
Study contacts
- Study coordinator: Emeli Månsson, PhD
- Email: emeli.mansson@regionvastmanland.se
- Phone: 004621173000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.