Understanding how alcohol affects people after sleeve gastrectomy
Pharmacokinetics and Responses to Alcohol After Bariatric Surgery
This study looks at how alcohol affects mood and blood sugar in people who have had sleeve gastrectomy compared to those who haven't, to see if there are differences between men and women.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 88 (estimated) |
| Ages | 21 Years to 64 Years |
| Sex | All |
| Sponsor | University of Illinois at Urbana-Champaign Academic / other |
| Locations | 1 site (Urbana, Illinois) |
| Trial ID | NCT06257771 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate how the body processes alcohol and its effects on mood and blood sugar in individuals who have undergone sleeve gastrectomy. It will compare men and women who had the surgery with matched controls who did not, focusing on differences in alcohol metabolism and glycemic responses. Participants will undergo two types of alcohol tests, either orally or intravenously, after fasting or eating. The study seeks to clarify the impact of alcohol consumption timing on blood sugar control and to explore sex-related differences in alcohol pharmacokinetics post-surgery.
Who should consider this trial
Good fit: Ideal candidates include men and women aged 21-64 who have undergone sleeve gastrectomy 1-5 years ago and consume alcohol within specified limits.
Not a fit: Patients with a history of alcohol use disorder or those with certain medical conditions that affect alcohol metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into safe alcohol consumption practices for patients after sleeve gastrectomy.
How similar studies have performed: While there is limited research specifically on alcohol metabolism post-sleeve gastrectomy, studies on alcohol effects in other surgical populations suggest potential for meaningful findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Surgery groups: * Male and female, 21-64 yrs. of age * Drink at least 1 standard drink per month but no more than 7 per week (women or \> 14 for men) * Underwent SG surgery 1-5 years ago Non-surgery control group * Male and female who did not undergo bariatric surgery * Age , BMI, race , and alcohol pattern of consumption equivalent to participants in the SG surgery groups Exclusion Criteria: * For all groups (surgery and non-surgery groups) * Smoking or having quit smoking less than 2 months ago * Pregnant or breastfeeding * Taking any medications that might affect alcohol metabolism * Anemia * Gastritis, colitis, Crohn's Disease, malabsorptive diseases, inflammatory diseases, liver disease, kidney disease, cancer less than five years ago, stroke, or severe organ dysfunction * Body weight \>450 pounds (because of a limit on body composition machine) * Alcohol use disorder * Regular use of drugs with addiction potential or regular misuse of substances * Abnormality on EKG as determined by a study physician to present a safety risk
Where this trial is running
Urbana, Illinois
- University of Illinois at Urbana Champaign — Urbana, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Marta Y Pepino de Gruev, PhD — University of Illinois at Urbana-Champaign
- Study coordinator: Mariel Molina-Castro, BS
- Email: marielm2@illinois.edu
- Phone: 217-300-4709
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.