Understanding how alcohol affects people after sleeve gastrectomy
Official title: Pharmacokinetics and Responses to Alcohol After Bariatric Surgery
Run by University of Illinois at Urbana-Champaign · NCT06257771 · Data updated 2026-11-12
This study looks at how alcohol affects mood and blood sugar in people who have had sleeve gastrectomy compared to those who haven't, to see if there are differences between men and women.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years to 64 Years |
| Sex | All |
| Enrollment | 88 (estimated) |
| Sponsor | University of Illinois at Urbana-Champaign Academic / other |
| Locations | 1 site (Urbana, Illinois) |
| Status | Recruiting |
| Started | July 31, 2024 |
| Main results expected | July 2028 |
| Study ends | August 2028 |
| Registry record updated | September 8, 2026 |
| Trial ID | NCT06257771 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include men and women aged 21-64 who have undergone sleeve gastrectomy 1-5 years ago and consume alcohol within specified limits.
✕Probably not a fit
Patients with a history of alcohol use disorder or those with certain medical conditions that affect alcohol metabolism may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate how the body processes alcohol and its effects on mood and blood sugar in individuals who have undergone sleeve gastrectomy. It will compare men and women who had the surgery with matched controls who did not, focusing on differences in alcohol metabolism and glycemic responses. Participants will undergo two types of alcohol tests, either orally or intravenously, after fasting or eating. The study seeks to clarify the impact of alcohol consumption timing on blood sugar control and to explore sex-related differences in alcohol pharmacokinetics post-surgery.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into safe alcohol consumption practices for patients after sleeve gastrectomy.
How similar studies have gone: While there is limited research specifically on alcohol metabolism post-sleeve gastrectomy, studies on alcohol effects in other surgical populations suggest potential for meaningful findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Surgery groups: * Male and female, 21-64 yrs. of age * Drink at least 1 standard drink per month but no more than 7 per week (women or \> 14 for men) * Underwent SG surgery 1-5 years ago Non-surgery control group * Male and female who did not undergo bariatric surgery * Age , BMI, race , and alcohol pattern of consumption equivalent to participants in the SG surgery groups Exclusion Criteria: * For all groups (surgery and non-surgery groups) * Smoking or having quit smoking less than 2 months ago * Pregnant or breastfeeding * Taking any medications that might affect alcohol metabolism * Anemia * Gastritis, colitis, Crohn's Disease, malabsorptive diseases, inflammatory diseases, liver disease, kidney disease, cancer less than five years ago, stroke, or severe organ dysfunction * Body weight \>450 pounds (because of a limit on body composition machine) * Alcohol use disorder * Regular use of drugs with addiction potential or regular misuse of substances * Abnormality on EKG as determined by a study physician to present a safety risk
Where it's running
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University of Illinois at Urbana Champaign
Urbana, Illinois, United States Recruiting
Study contacts
- Principal investigator: Marta Y Pepino de Gruev, PhD — University of Illinois at Urbana-Champaign
- Study coordinator: Rafael Guimaraes de Lima, PhD
- Email: rafael5@illinois.edu
- Phone: 217-300-2374
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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15-year outcomes after sleeve gastrectomy in France
This study looks at how people who had sleeve gastrectomy have fared over 15 years to see long-term weight changes and health effects.
-
Extra daily iron after sleeve gastrectomy to prevent anemia
This study tests whether taking an extra daily iron pill plus a multivitamin prevents iron deficiency anemia in adults during the six months after sleeve gastrectomy compared with taking a multivitamin alone.
-
Foot reflexology to reduce nausea after sleeve gastrectomy
This will try foot reflexology to see if it reduces nausea and vomiting in adults after sleeve gastrectomy.
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Digestion and gut function after bariatric surgery
This project will test how digestion — including enzymes, bile acids, pH, and transit time — works in adults with obesity and in people at least one year after Roux‑en‑Y or sleeve gastrectomy by collecting intestinal samples and using a swallowable sensor capsule.
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Vestibular and balance changes before and after sleeve gastrectomy
This study will see if vestibular (balance) function improves in adults having sleeve gastrectomy for severe obesity by testing them before surgery and at one and six months after surgery.
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Link between MASH and mitochondrial membrane changes in people having bariatric surgery.
We will test whether changes in mitochondria-associated membranes (MAMs) in liver cells and blood immune cells are linked to MASH in adults undergoing bariatric surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.