Understanding frailty and recovery in critically ill COVID-19 and respiratory infection survivors
REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or Acute Respiratory Infection
This study looks at how frailty affects the recovery and health of adults and children who were critically ill with COVID-19 or respiratory infections, and whether rehabilitation can help them feel better afterward.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 900 (estimated) |
| Sex | All |
| Sponsor | McMaster University Academic / other |
| Locations | 28 sites (Calgary, Alberta and 27 other locations) |
| Trial ID | NCT05246098 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the impact of frailty on the survival and health outcomes of critically ill adults and children who have suffered from COVID-19 or acute respiratory infections. By analyzing data from patients admitted to intensive care units, the researchers will assess whether frailty correlates with lower survival rates and increased health complications post-ICU. The study will also explore the role of rehabilitation in improving the quality of life for these survivors. The findings could provide valuable insights into the management of critically ill patients with frailty.
Who should consider this trial
Good fit: Ideal candidates include adult and pediatric survivors of COVID-19 or acute respiratory infections who were admitted to intensive care units and required advanced life support.
Not a fit: Patients who were admitted to the ICU for less than 24 hours will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved care strategies for critically ill patients, enhancing their recovery and quality of life.
How similar studies have performed: While there is ongoing research into the effects of frailty in critically ill patients, this specific focus on COVID-19 and acute respiratory infections in both adults and children is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult and pediatric survivors of COVID-19 or acute respiratory infection admitted to participating intensive care units (ICUs) and PICUs. The investigators define children as less than, and adults as greater than or equal to, 18 years old, respectively. The investigators will include adults and pediatrics with a confirmed diagnosis of COVID-19, pediatric patients with MIS-C, and adults and pediatrics with suspected or proven acute respiratory infection with onset within 14 days of ICU/PICU admission and requiring invasive mechanical ventilation, non-invasive ventilation, or high flow oxygen therapy. Exclusion Criteria: * Patients who were admitted to ICU for \<24 hours
Where this trial is running
Calgary, Alberta and 27 other locations
- Alberta Children's Hospital — Calgary, Alberta, Canada (Active_not_recruiting)
- University of Alberta — Edmonton, Alberta, Canada (Recruiting)
- Sturgeon Community Hopsital — St. Albert, Alberta, Canada (Not_yet_recruiting)
- Royal Columbian Hospital — New Westminster, British Columbia, Canada (Not_yet_recruiting)
- Children's Hospital of Winnipeg — Winnipeg, Manitoba, Canada (Active_not_recruiting)
- QEII Health Sciences Centre — Halifax, Nova Scotia, Canada (Recruiting)
- Izaak Walton Killam Hospital for Children — Halifax, Nova Scotia, Canada (Recruiting)
- Brantford General Hospital — Brantford, Ontario, Canada (Recruiting)
- Hamilton General Hospital — Hamilton, Ontario, Canada (Recruiting)
- St. Joseph's Healthcare Intensive Care Unit — Hamilton, Ontario, Canada (Recruiting)
- McMaster Children's Hospital — Hamilton, Ontario, Canada (Active_not_recruiting)
- Juravinski Hospital — Hamilton, Ontario, Canada (Recruiting)
- Kingston Health Sciences Centre — Kingston, Ontario, Canada (Recruiting)
- London Health Sciences Centre — London, Ontario, Canada (Active_not_recruiting)
- Children's Hospital of Eastern Ontario — Ottawa, Ontario, Canada (Active_not_recruiting)
- The Ottawa Hospital — Ottawa, Ontario, Canada (Recruiting)
- Niagara Health System — St. Catharines, Ontario, Canada (Recruiting)
- Sunnybrook Hospital — Toronto, Ontario, Canada (Recruiting)
- St. Michael's Hospital — Toronto, Ontario, Canada (Recruiting)
- The Hospital for Sick Children — Toronto, Ontario, Canada (Active_not_recruiting)
- Hôpital Hôtel-Dieu de Lévis — Lévis, Quebec, Canada (Recruiting)
- Centre hospitalier de l'Université de Montréal — Montreal, Quebec, Canada (Recruiting)
- The Centre hospitalier universitaire Sainte-Justine — Montreal, Quebec, Canada (Not_yet_recruiting)
- Montreal Children's Hospital — Montreal, Quebec, Canada (Active_not_recruiting)
- Hôpital du Sacré-Cœur de Montréal — Montreal, Quebec, Canada (Recruiting)
- Institut Universitaire de Cardiologie et de Pneumologie de Québec — Québec, Quebec, Canada (Recruiting)
- Hôpital Fleurimont - Sherbrooke — Sherbrooke, Quebec, Canada (Recruiting)
- Saskatchewan Health Authority — Regina, Saskatchewan, Canada (Recruiting)
Study contacts
- Principal investigator: Michelle E Kho, PT, PhD — McMaster University
- Study coordinator: Geoff Strong, PT, MS
- Email: revive@mcmaster.ca
- Phone: 905-522-1155
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.