Understanding factors influencing childhood obesity and diabetes in families
Official title: Genetic and Environmental Influences on Development of Type 2 Diabetes in Childhood: The Next Generation Longitudinal Birth Cohort.
Run by University of Manitoba · NCT04621396 · Data updated 2026-11-12
This study looks at how parents' health and lifestyle choices affect the risk of obesity and type 2 diabetes in their children, while also trying to find ways to prevent these conditions through community support.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | University of Manitoba Academic / other |
| Locations | 1 site (Winnipeg, Manitoba) |
| Status | Recruiting |
| Started | September 2013 |
| Main results expected | December 31, 2026 |
| Study ends | December 2028 |
| Registry record updated | July 2, 2026 |
| Trial ID | NCT04621396 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include pregnant women with type 2 diabetes, gestational diabetes, or no diabetes who identify as Indigenous and reside in Manitoba.
✕Probably not a fit
Patients with type 1 diabetes or those residing outside of Manitoba may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the roles of maternal and paternal factors, intrauterine exposures, genetic influences, and postnatal environments on the development of obesity and youth-onset type 2 diabetes in children. By clinically and metabolically profiling parents and their offspring, the study seeks to identify risk factors associated with these conditions. It will also evaluate the impact of maternal diabetes on the risk of obesity and diabetes in children and explore modifiable risk factors. Additionally, the study plans to develop a community-based breastfeeding intervention to prevent diabetes in at-risk offspring.
Why it matters
Potential benefit: If successful, this study could lead to targeted interventions that reduce the risk of obesity and type 2 diabetes in children from high-risk families.
How similar studies have gone: Other studies have shown success in identifying risk factors for obesity and diabetes in children, making this approach promising but not entirely novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes. * From self-identified Indigenous heritage (e.g., Cree, Oji-Cree, Métis, Anishinaabe, etc.). * Are delivering and residing in Manitoba. * Mother/Father and children must be biological family members. Exclusion Criteria: * Mothers or children with type 1 diabetes. * Residing outside of Manitoba.
Where it's running
-
Children's Hospital Research Institute of Manitoba/University of Manitoba
Winnipeg, Manitoba, Canada Recruiting
Study contacts
- Principal investigator: Brandy A Wicklow, MD, MSc — University of Manitoba, Children's Hospital Research Institute of Manitoba
- Study coordinator: Brandy A Wicklow, MD, MSc
- Email: bwicklow@hsc.mb.ca
- Phone: 204-787-1222
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Lifestyle Metabotype Study B: Understanding Personalized Glucose Responses
This study tests how lifestyle, metabolism, and brain energy use relate to each person’s blood sugar response after meals, across people with and without prediabetes or type 2 diabetes.
-
Lifestyle Metabotype Study: How Daily Habits Shape Blood Sugar
This observational study tests whether personal lifestyle and biological factors can predict how a person’s blood sugar responds after meals.
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Switching to Zenagamtide From Tirzepatide in Adults With Overweight or Obesity With or Without Type 2 Diabetes
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.