Clinical trial Recruiting at 1 site Observational Ages Any age to 18

Understanding factors influencing childhood obesity and diabetes in families

Official title: Genetic and Environmental Influences on Development of Type 2 Diabetes in Childhood: The Next Generation Longitudinal Birth Cohort.

Run by University of Manitoba · NCT04621396 · Data updated 2026-11-12

This study looks at how parents' health and lifestyle choices affect the risk of obesity and type 2 diabetes in their children, while also trying to find ways to prevent these conditions through community support.

More Type 2 Diabetes trials

Quick facts

Study typeObservational
AgesAny age to 18 Years
SexAll
Enrollment600 (estimated)
SponsorUniversity of Manitoba
Academic / other
Locations1 site (Winnipeg, Manitoba)
StatusRecruiting
StartedSeptember 2013
Main results expectedDecember 31, 2026
Study endsDecember 2028
Registry record updatedJuly 2, 2026
Trial IDNCT04621396 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include pregnant women with type 2 diabetes, gestational diabetes, or no diabetes who identify as Indigenous and reside in Manitoba.

Probably not a fit

Patients with type 1 diabetes or those residing outside of Manitoba may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the roles of maternal and paternal factors, intrauterine exposures, genetic influences, and postnatal environments on the development of obesity and youth-onset type 2 diabetes in children. By clinically and metabolically profiling parents and their offspring, the study seeks to identify risk factors associated with these conditions. It will also evaluate the impact of maternal diabetes on the risk of obesity and diabetes in children and explore modifiable risk factors. Additionally, the study plans to develop a community-based breastfeeding intervention to prevent diabetes in at-risk offspring.

Why it matters

Potential benefit: If successful, this study could lead to targeted interventions that reduce the risk of obesity and type 2 diabetes in children from high-risk families.

How similar studies have gone: Other studies have shown success in identifying risk factors for obesity and diabetes in children, making this approach promising but not entirely novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes.
* From self-identified Indigenous heritage (e.g., Cree, Oji-Cree, Métis, Anishinaabe, etc.).
* Are delivering and residing in Manitoba.
* Mother/Father and children must be biological family members.

Exclusion Criteria:

* Mothers or children with type 1 diabetes.
* Residing outside of Manitoba.

Where it's running

  • Children's Hospital Research Institute of Manitoba/University of Manitoba
    Winnipeg, Manitoba, Canada
    Recruiting

Study contacts

  • Principal investigator: Brandy A Wicklow, MD, MSc — University of Manitoba, Children's Hospital Research Institute of Manitoba
  • Study coordinator: Brandy A Wicklow, MD, MSc
  • Email: bwicklow@hsc.mb.ca
  • Phone: 204-787-1222

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.