Acute Blood Flow Restriction Walking in Type 2 Diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial, adults with type 2 diabetes will be assigned to either regular treadmill walking or treadmill walking with blood flow restriction. Both groups will walk 32 minutes at a level that targets 40-50% of heart rate reserve, with the BFR cuffs inflated to 60% of limb occlusion pressure and deflated briefly every 10 minutes for safety. Blood samples will be collected before exercise, near the end of the final occlusion cycle, and during recovery to assess immune cell counts, function, and phenotype. The study aims to understand how BFR during aerobic exercise may influence immune responses in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 19-64 years
* Diagnosed with type 2 diabetes with current HbA1c 5.7-9.0%
* Completing \<150 minutes of moderate-vigorous physical activity per week.

Exclusion Criteria:

* Chronic musculoskeletal condition or recent (within 2 years) cardiovascular event preventing participation in exercise.
* Unstable type 2 diabetes medication of the last 3 months
* Absolute contraindications to BFR (i.e., peripheral vascular disease)
* A self-reported diagnosis of low iron concentrations, anemia, or being treated for these conditions
* A diagnosis of any red blood cell-altering condition (i.e., sickle cell anemia, poikilocytosis)
* Currently living with any cardiovascular disease, which would impact the ability to participate in exercise safely
* Currently prescribed any medication which would impact the ability to use a heart rate monitor to accurately track intensity

Where it's running

• University of British Columbia Okanagan
  Kelowna, British Columbia, Canada Recruiting

Study contacts

• Study coordinator: Jonathan P Little, PhD
• Email: jonathan.little@ubc.ca
• Phone: 250-807-9876

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Continuous Glucose Monitoring in Type 2 Diabetes Not on Insulin

  This study tests whether using a continuous glucose monitoring system helps people with type 2 diabetes who aren’t using insulin to improve blood sugar control and quality of life.

  Recruiting Medical University of Bialystok · Bialystok · NCT07919236

• Differentiating heart disease in autoimmune vs. type 2 diabetes

  This study tests whether adult-onset autoimmune diabetes (AID/LADA) and type 2 diabetes (T2D) differ in how diabetic heart disease develops, using advanced heart imaging in people with AID, T2D, and healthy controls.

  Recruiting University of Roma La Sapienza · Rome, Roma · NCT07911007

• Lifestyle Metabotype Study B: Understanding Personalized Glucose Responses

  This study tests how lifestyle, metabolism, and brain energy use relate to each person’s blood sugar response after meals, across people with and without prediabetes or type 2 diabetes.

  Recruiting at 2 sites German Institute of Human Nutrition · Berlin and 1 other locations · NCT07888257

• Lifestyle Metabotype Study: How Daily Habits Shape Blood Sugar

  This observational study tests whether personal lifestyle and biological factors can predict how a person’s blood sugar responds after meals.

  Recruiting German Institute of Human Nutrition · Potsdam, Potsdam-Rehbrücke · NCT07868601

• Switching to Zenagamtide From Tirzepatide in Adults With Overweight or Obesity With or Without Type 2 Diabetes

  This study tests whether adults who are overweight or have obesity (with or without type 2 diabetes) can switch from tirzepatide to a new treatment called zenagamtide to find a tolerable dose.

  Recruiting at 2 sites Phase 1 Novo Nordisk A/S · Glendale, California and 1 other locations · NCT07868354

• Diabetes Medical Nutrition Therapy for type 2 diabetes in a large health system

  This pilot trial tests a Diabetes Medical Nutrition Therapy program for adults with type 2 diabetes and poor blood sugar control within a big health system to see how well it can be implemented and if it helps improve readings.

  Recruiting Kaiser Permanente · Fontana, California · NCT07868250

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.