Understanding cognitive outcomes after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate cognitive outcomes in stroke patients by examining the long-term effects of stroke on brain function. Researchers will assess blood-brain barrier permeability, identify blood biomarkers related to angiogenesis, and explore their relationship with cognitive decline. Participants will undergo cognitive testing and MRIs two years apart, and their outcomes will be compared to non-stroke patients with cardiovascular risk factors. The study seeks to uncover potential mechanisms behind post-stroke dementia and establish biomarkers for predicting cognitive decline.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 45 years or over
* One or more vascular risk factors (e.g. high blood pressure, diabetes or vascular disease such as angina, a previous heart attack, a heart bypass or peripheral artery disease in the legs)
* Established vascular disease (previous MI, angina, vascular stent in the peripheral bed)
* Sufficiently fluent in written and spoken English
* Living independently in the community
* Willing/able to give consent to study participation.

Exclusion Criteria:

* Current treatment with IL-1 blockade or established immune-suppressant therapy (e.g. IL-1Ra or IL-1 antibodies), or treatment within the last 3 months
* Currently participating in a clinical trial of investigation medicinal product (CTIMP) or device trial.
* No history of any previous ischaemic or haemorrhagic stroke, a mini-stroke or a serious brain injury
* Do not have dementia
* Renovascular Disease
* Major neurological disease (immune mediated, previous brain tumors)

Where it's running

• Stanford University Hospital
  Palo Alto, California, United States Recruiting

Study contacts

• Principal investigator: Marion Buckwalter, MD — Stanford University
• Study coordinator: Muhith Musabbir
• Email: musabbir@stanford.edu
• Phone: 650-723-8886

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Deep phenotyping to explore recovery in young adults after stroke

  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

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• Stem cell therapy for chronic stroke recovery

  This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.

  Recruiting Phase 2 Hokkaido University Hospital · Sapporo, Hokkaido · NCT06752720

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

  This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07921108

• Remote Ischaemic Conditioning for Fatigue After Stroke 2

  Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.