Understanding circadian rhythms and risk factors in dementia patients
Circadian Rhythm and Other Individual Factors Among Memory Clinic Patients
Assistance Publique - Hôpitaux de Paris · NCT05977712
This study is trying to find out how daily body clock patterns and other personal factors affect different types and stages of dementia to help with early diagnosis and understanding how the disease progresses.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 2 sites (Paris, France and 1 other locations) |
| Trial ID | NCT05977712 on ClinicalTrials.gov |
What this trial studies
The CIRCAME project is an observational study conducted at two memory clinics in Paris, focusing on identifying circadian rhythm components and individual risk factors associated with various subtypes and stages of dementia. It aims to develop cost-effective screening tools for early diagnosis in primary care settings, independent of known risk factors. Additionally, the study seeks to understand factors related to the progression of dementia, including cognitive decline and daily living limitations, over a period of up to 15 years. Participants will undergo clinical examinations, questionnaires, and eye assessments to gather comprehensive data.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and over who are patients at the participating memory clinics and can provide informed consent.
Not a fit: Patients with psychiatric disorders that could explain cognitive symptoms or those unable to participate due to severe cognitive impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early diagnosis and management of dementia, enhancing patient care and outcomes.
How similar studies have performed: While the approach of using circadian rhythms in dementia assessment is innovative, similar studies have shown promise in understanding risk factors for dementia.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient of legal age (18 or over) * Signed informed consent form * Patient affiliated to the french social security system Exclusion Criteria: * Skin allergy to plastic * Diagnosis of psychiatric disorder that can explain all cognitive symptoms * Inability to come accompanied for patients with a Mini-Mental State Examination (MMSE) cognitive score ≤18 or a clinician assessment indicating the need to be accompanied (e.g. wheelchair use, agitation) * Participation at the time of inclusion and during the 9-day period of wearing the accelerometer in interventional research with potential impact on circadian rhythm
Where this trial is running
Paris, France and 1 other locations
- Centre de neurologie Cognitive / CMRR — Paris, France, France (RECRUITING)
- Hôpital de Jour Gériatrique et consultation mémoire — Paris, France, France (RECRUITING)
Study contacts
- Study coordinator: Claire PAQUET, MDPhD
- Email: claire.paquet@aphp.fr
- Phone: 0140054313
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Dementia, Circadian rhythm, Sleep disturbance, APOE, Retinal measures, Dementia subtypes, stages and progression, Alzheimer's disease, Lewy body dementia