Understanding chronic kidney transplant rejection and complications
Australian Genomics Of Chronic Allograft Dysfunction Study
This study looks at kidney transplant patients to see how different biological factors affect the chances of rejection and complications after their transplant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Western Sydney Local Health District Academic / other |
| Locations | 2 sites (Westmead, New South Wales and 1 other locations) |
| Trial ID | NCT06314230 on ClinicalTrials.gov |
What this trial studies
The Australian Genomics of Chronic Allograft Dysfunction (AUSCAD) study is an observational study conducted at Westmead Hospital that enrolls patients at the time of kidney transplantation and monitors their post-transplant journey. The study aims to uncover correlations between chronic rejection, graft loss, and various biological factors such as allograft reactivity and gene expression. By tracking these outcomes, the study seeks to generate new insights that could enhance the management and success of kidney transplants.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-75 who are undergoing kidney transplantation, either from living or deceased donors.
Not a fit: Patients who are presensitized, recipients of multiple organ transplants (except kidney/pancreas), or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing chronic rejection and enhancing kidney transplant outcomes.
How similar studies have performed: Other studies have explored similar genomic approaches in transplant settings, showing promise in understanding transplant rejection, but this specific study's approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Living or deceased donor kidney transplant candidate. * Biological sex: any * Ages: 18-75 years. * Subject must be able to understand and provide informed consent. * Deceased donor individuals where Research Consent has been obtained from the person consenting to organ donation at the time of organ retrieval. * Identifiable living donors who have received informed consent and have consented to participate in the project. Exclusion Criteria: * Presensitization in living donor recipients prior to transplantation, as determined by site-specific standards, OR positive cross match according to site specific technique in cadaveric donor recipients. * Recipients of multiple organ transplants, with the exception of kidney/pancreas transplants. * Inability or unwillingness of a participant to give written informed consent or comply with study protocol * High risk populations including pregnant women, children less than 18 years and prisoners will not be included in the study. * Non English speaking potential participants who do not understand the requirements of the study will not be included.
Where this trial is running
Westmead, New South Wales and 1 other locations
- Westmead Hospital — Westmead, New South Wales, Australia (Recruiting)
- Westmead Institute for Medical Research — Westmead, New South Wales, Australia (Recruiting)
Study contacts
- Study coordinator: Jennifer SY Li, MBBS, FRACP
- Email: jennifer.li@health.nsw.gov.au
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.