Understanding cardiovascular risk in COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to measure inflammation, oxidative stress, and various functional parameters in patients with chronic obstructive pulmonary disease (COPD) to identify indicators of cardiovascular risk. The study will follow a cohort of COPD patients over five years, combining data from an existing group and a new group of patients. By analyzing these parameters, the researchers hope to gain insights into the relationship between COPD and cardiovascular health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For patients with stable COPD:

* Men or women aged 18 to 85
* FEV1/FVC \< 70% or proven BPCO
* Patients who have given their free and informed consent in writing

For patients with decompensated COPD:

* Men or women aged 18 to 85
* FEV1/FVC \< 70% or proven BPCO
* At the time of acute respiratory failure (ARF), when admitted to hospital:

  * Respiratory rate \> 25 cycles per minute
  * PaCO2 \> 45 mmHg
  * blood pH \< 7.35
* When included in the study:

  * pH \> 7.33 at the end of ARF, 2 days in a row, or 3 to 7 days post-D1 decompensation (admission to the hospital)
  * Fever \< 38.5°C
* Patients who have given their free and informed consent in writing

Exclusion Criteria:

* Obvious evolving infection or CRP \> 100 mg/L
* Cardiac decompensation considered the main cause of decompensation or chronic heart failure with LVEF \< 45%
* Evolving neoplasia
* On antioxidants: N-acetyl-cysteine, selenium, vit. C, vit. E
* Pregnant or nursing women
* Patients under tutorship or curatorship
* Patients participating in a drug clinical research study
* Patients not affiliated to the French social security system (or equivalent)
* Patients deprived of liberty or hospitalized without consent.

Where it's running

• University Grenoble Hospital
  Grenoble, La Tronche, France Recruiting

Study contacts

• Principal investigator: Jean-Louis PEPIN, ProfessorPHD — University Grenoble Hospital
• Study coordinator: Jean-Louis PEPIN, ProfessorPHD
• Email: JPepin@chu-grenoble.fr
• Phone: +33 476 768 473

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.