Understanding cardiac dysfunction in septic shock patients
Sepsis in the Intensive Care Unit-II
Linkoeping University · NCT04695119
This study is trying to understand how heart problems in patients with septic shock affect their recovery and survival.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 330 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Linkoeping University (other gov) |
| Locations | 4 sites (Dijon and 3 other locations) |
| Trial ID | NCT04695119 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the complexities of sepsis-induced cardiac dysfunction, particularly focusing on both systolic and diastolic dysfunction in patients experiencing septic shock. The study will collect data on various factors, including the impact of previous cardiovascular conditions, the use of vasopressors and inotropic drugs, and mechanical ventilation on patient outcomes. By analyzing these variables, the researchers hope to clarify the relationship between cardiac dysfunction and mortality in septic patients. The study has already recruited 70 patients across four centers and will continue recruitment through 2023.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients admitted to the ICU who meet the Sepsis-III criteria for septic shock.
Not a fit: Patients with acute coronary syndromes or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiac dysfunction in septic shock, potentially enhancing patient outcomes.
How similar studies have performed: While the phenomenon of sepsis-induced cardiac dysfunction is recognized, this study's specific focus on its various aspects is relatively novel and underexplored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients admitted to ICU and fulfilling the Sepsis-III criteria for septic shock Exclusion Criteria: * No informed consent * Acute coronary syndromes
Where this trial is running
Dijon and 3 other locations
- CHU Dijon-Bourgogne — Dijon, France (RECRUITING)
- CHU Georges Pompidou — Paris, France (RECRUITING)
- Ryhov Sjukhus Jönköping — Jönköping, Sweden (NOT_YET_RECRUITING)
- Dept of Anaesthesia and Intensive Care — Linköping, Sweden (RECRUITING)
Study contacts
- Principal investigator: Bernard Cholley, MD, PhD — CHU George Pompidou
- Study coordinator: Michelle S Chew, MBBS, PHD
- Email: michelle.chew@liu.se
- Phone: +46101030000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Septic Shock, Sepsis, Cardiomyopathies, Organ Failure, Multiple