Understanding brain activity changes during ketamine treatment for psychiatric disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to investigate how ketamine affects brain activity and leads to dissociative symptoms in patients undergoing antidepressant therapy. By recording neural circuits during cognitive tasks, the study seeks to uncover the mechanisms behind the therapeutic effects of ketamine and its side effects. The focus is on patients in clinical neuro inpatient units at Stanford Medical Center, where the effects of ketamine will be closely monitored and analyzed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient in clinical neuro inpatient units at Stanford Medical Center
* Age \>18 years old
* Female participants are expected to use an effective method of birth control throughout the study which includes: hormonal methods (birth control pills, patches, injections, vaginal ring or implants), barrier methods (condom or diaphragm) used with spermicide, intrauterine device (IUD), or abstinence (no sex)

Exclusion Criteria:

* Lifetime psychotic disorder
* Pregnant or nursing females
* Prior adverse ketamine response
* Use of ketamine in past 7 days

Where it's running

• Stanford University
  Palo Alto, California, United States Recruiting

Study contacts

• Principal investigator: Karl Deisseroth, MD, PhD — Stanford University
• Study coordinator: Arjay Cordero
• Email: arjayc@stanford.edu
• Phone: 650-580-9000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Brief Suicidal Crisis Prevalence in Psychiatric Settings

  This observational study tests how common a brief suicidal crisis (under 24 hours) is among adults seen by psychiatrists in Clermont-Ferrand, France.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07740356

• Brief Case Management to Help Personal Recovery after Involuntary Psychiatric Admission

  This trial tests whether a Brief Case Management approach helps people who were involuntarily admitted to a psychiatric hospital recover personally and avoid another involuntary readmission.

  Recruiting University of Lausanne Hospitals · Lausanne, Canton of Vaud · NCT07497763

• Sailing to support psychosocial rehabilitation

  This project tries sailing activities alongside usual care to see if they help adults with psychiatric or neurodevelopmental disorders who live in Seine-Saint-Denis.

  Recruiting at 2 sites Centre hospitalier de Ville-Evrard, France · Neuilly-sur-Marne and 1 other locations · NCT07354633

• Group classes to support independent living for people with severe psychiatric disorders

  This project will try group psychoeducation sessions for people with severe psychiatric disorders and their carers to see if it helps them live more independently at home.

  Recruiting Centre hospitalier de Ville-Evrard, France · Neuilly-sur-Marne · NCT07317388

• Adapted HOPE workshop to reduce burnout for gynecologic oncology clinicians

  This program will test whether an adapted HOPE workshop can help gynecologic oncology clinicians reduce stress and burnout.

  Recruiting Fred Hutchinson Cancer Center · Seattle, Washington · NCT07282158

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.