Understanding biomarkers in patients with Multiple Sclerosis receiving stem cell treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the underlying disease mechanisms in patients with relapsing-remitting Multiple Sclerosis (MS) who have undergone autologous haematopoietic stem cell transplantation (aHSCT). By analyzing biological samples and conducting clinical assessments, the study seeks to identify biomarkers that may predict treatment response and disease progression. The research builds on the experience of over 1800 patients treated in Europe, focusing on improving outcomes for those who do not respond optimally to aHSCT. The findings could enhance understanding of MS and inform future treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosis of a immune mediated neurological disease according to disease specific criteria (active treatment arm) or diagnosis of relapsing remitting multiple sclerosis (control arm).
2. Treatment with autologous haematopoetic stem cell transplantation (active treatment arm) or high efficacy disease modifying treatment (control arm).
3. Willing to provide biological samples for analysis and undergo clinical assessments for the duration of follow up.
4. Able to understand English and provide informed consent.

Exclusion Criteria:

1\. Inability to provide informed consent.

Where it's running

• Sheffield Teaching Hospitals NHS Foundation Trust
  Sheffield, England, United Kingdom Recruiting

Study contacts

• Principal investigator: Gavin Brittain, MBBS, MRCP — Sheffield Teaching Hospitals NHS Foundation Trust and The University of Sheffield
• Study coordinator: Gavin Brittain, MBBS, MRCP
• Email: gavin.brittain@sheffield.ac.uk
• Phone: +44114 271 1900

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.