Understanding Basal Cell Function in Chronic Rhinosinusitis with Nasal Polyps
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
This study is trying to understand how certain cells in the nose work differently in people with chronic sinus issues and nasal polyps compared to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Trial ID | NCT06129552 on ClinicalTrials.gov |
What this trial studies
This project aims to explore the differences in basal cell functions and their interactions with immune cells in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) compared to healthy controls. Using surgically resected samples, the study will investigate epithelial cell populations, gene expression patterns, and the activation of basal cells in response to environmental triggers. The research will also examine the chemotactic properties of secreted proteins from basal cells and their interactions with regulatory T cells. This observational study will provide insights into the pathogenic mechanisms underlying CRSwNP.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over the age of 18 who do not have chronic rhinosinusitis with nasal polyps or allergic rhinitis.
Not a fit: Patients with chronic rhinosinusitis with nasal polyps or allergic rhinitis will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of the mechanisms driving chronic rhinosinusitis with nasal polyps, potentially informing new therapeutic strategies.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding the role of immune cell interactions in chronic inflammatory conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over the age of 18 * Males and females Exclusion Criteria: * CRSwNP * AR * Smoker, or \< 1-year ex-smoker * Underlying systematic pathology (Morbus Wegener or Churg Strauss Syndrome for example)
Where this trial is running
Leuven
- Peter Hellings — Leuven, Belgium (Recruiting)
Study contacts
- Study coordinator: Peter Hellings, MD, PhD
- Email: peter.hellings@uzleuven.be
- Phone: +32 16 33 23 42
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.