Understanding Basal Cell Function in Chronic Rhinosinusitis with Nasal Polyps

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to explore the differences in basal cell functions and their interactions with immune cells in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) compared to healthy controls. Using surgically resected samples, the study will investigate epithelial cell populations, gene expression patterns, and the activation of basal cells in response to environmental triggers. The research will also examine the chemotactic properties of secreted proteins from basal cells and their interactions with regulatory T cells. This observational study will provide insights into the pathogenic mechanisms underlying CRSwNP.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over the age of 18
* Males and females

Exclusion Criteria:

* CRSwNP
* AR
* Smoker, or \< 1-year ex-smoker
* Underlying systematic pathology (Morbus Wegener or Churg Strauss Syndrome for example)

Where it's running

• Peter Hellings
  Leuven, Belgium Recruiting

Study contacts

• Study coordinator: Peter Hellings, MD, PhD
• Email: peter.hellings@uzleuven.be
• Phone: +32 16 33 23 42

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.