Understanding Atrial Fibrillation Dynamics
Official title: The Dynamics of Human Atrial Fibrillation
Run by Stanford University · NCT05366361 · Data updated 2026-11-12
This study is trying to find out how different treatments for atrial fibrillation work for individual patients to improve their chances of success and lower risks.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 22 Years to 80 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Stanford University Academic / other |
| Locations | 1 site (Stanford, California) |
| Status | Recruiting |
| Started | August 18, 2020 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2027 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT05366361 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients referred for ablation or Maze surgery at Stanford Medicine for persistent atrial fibrillation who have failed or are intolerant to at least one anti-arrhythmic drug.
✕Probably not a fit
Patients with active coronary ischemia, decompensated heart failure, or other specified exclusion criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to develop a framework for understanding atrial fibrillation (AF) by identifying patients who will respond to various therapies, including pulmonary vein isolation (PVI) and Maze surgery. The study will utilize non-invasive electrocardiographic imaging (ECGI) and intracardiac recordings to assess the relationship between organized and disorganized AF areas and patient outcomes. By focusing on personalized therapy, the study seeks to improve procedural success rates and reduce risks associated with unsuccessful treatments.
Why it matters
Potential benefit: If successful, this study could lead to more effective, personalized treatment strategies for patients with atrial fibrillation.
How similar studies have gone: Other studies have shown promise in using personalized approaches to treat atrial fibrillation, but this specific framework is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * referred for ablation or Maze surgery at Stanford Medicine for persistent AF (i.e. which requires cardioversion to terminate and/or lasts \>7 days) * Per our clinical practice and guidelines (Calkins et al., Heart Rhythm 2018), patients will have failed or be intolerant of \>or= 1 anti-arrhythmic drug. Patients after Maze surgery typically have failed prior endocardial ablation. Exclusion Criteria: * active coronary ischemia or decompensated heart failure * atrial or ventricular clot on trans-esophageal echocardiography * pregnancy (to minimize fluoroscopic exposure) * inability or unwillingness to provide informed consent * rheumatic valve disease (results in a unique AF phenotype) * thrombotic disease or venous filters * prior chest surgery is a relative contraindication for Maze surgery
Where it's running
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Stanford University
Stanford, California, United States Recruiting
Study contacts
- Study coordinator: Anson Lee, MD
- Email: ansonlee@stanford.edu
- Phone: (650) 724-7500
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Volta AI software in real-world AF ablation
A real-world observational study will test the latest Volta AF-Xplorer II AI software during atrial fibrillation ablation to see how safe and effective it is over 24 months.
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This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.
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Sensor-guided exercise program for people with atrial fibrillation
This program will test whether a Fitbit-based, personalized exercise plan can reduce symptoms and episode burden in people with paroxysmal atrial fibrillation.
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This study looks at how bleeding in the brain affects both the brain and the heart in adults to better understand the connection between these injuries.
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Comparing CT and DSA for selecting LAA occluder sizes in heart procedures
This study is testing whether using CT or DSA imaging helps doctors choose the right size of heart device for patients with atrial fibrillation who need a specific procedure.
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Ablation of focal activation in atrial fibrillation
This study is testing a new method to find specific electrical signals that may be causing ongoing atrial fibrillation in patients, to see if targeting these signals can improve their treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.